Literature DB >> 6470740

Antigalactocerebroside serum demyelinates optic nerve in vivo.

R C Sergott, M J Brown, D H Silberberg, R P Lisak.   

Abstract

Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of anti-GalC serum. Demyelination appears to result from primary damage to oligodendrocytes.

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Year:  1984        PMID： 6470740     DOI： 10.1016/0022-510x(84)90177-1

Source DB:  PubMed          Journal:  J Neurol Sci        ISSN： 0022-510X            Impact factor:   3.181


  9 in total

1.  Suppression of the onset of myelination extends the permissive period for the functional repair of embryonic spinal cord.

Authors:  H S Keirstead; S J Hasan; G D Muir; J D Steeves
Journal:  Proc Natl Acad Sci U S A       Date:  1992-12-15       Impact factor: 11.205

2.  Oligodendrocytes and oligodendrocyte/type-2 astrocyte progenitor cells of adult rats are specifically susceptible to the lytic effects of complement in absence of antibody.

Authors:  D R Wren; M Noble
Journal:  Proc Natl Acad Sci U S A       Date:  1989-11       Impact factor: 11.205

Review 3.  Optic nerve sheath decompression: neuropathologic, clinical, and hemodynamic results and rationale.

Authors:  R C Sergott
Journal:  Trans Am Ophthalmol Soc       Date:  1991

4.  Neuropsychiatric manifestations of systemic lupus erythematosus: the value of anticardiolipin, antigangliosides and antigalactocerebrosides antibodies.

Authors:  L T Costallat; R M de Oliveira; M B Santiago; W Cossermelli; A M Samara
Journal:  Clin Rheumatol       Date:  1990-12       Impact factor: 2.980

Review 5.  MS as autoimmune disease: myelin antigens.

Authors:  W Fierz
Journal:  Res Immunol       Date:  1989-02

6.  In vivo CNS demyelination mediated by anti-galactocerebroside antibody.

Authors:  K Ozawa; T Saida; K Saida; H Nishitani; M Kameyama
Journal:  Acta Neuropathol       Date:  1989       Impact factor: 17.088

7.  Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

Authors:  C Linington; M Bradl; H Lassmann; C Brunner; K Vass
Journal:  Am J Pathol       Date:  1988-03       Impact factor: 4.307

8.  Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions.

Authors:  H Lassmann; C Brunner; M Bradl; C Linington
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

9.  Monoclonal antibody to Theiler's murine encephalomyelitis virus defines a determinant on myelin and oligodendrocytes, and augments demyelination in experimental allergic encephalomyelitis.

Authors:  M Yamada; A Zurbriggen; R S Fujinami
Journal:  J Exp Med       Date:  1990-06-01       Impact factor: 14.307
  9 in total

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