| Literature DB >> 6469389 |
M R Kilbourn, M J Welch, C S Dence, T J Tewson, H Saji, M Maeda.
Abstract
Syntheses of [18F]haloperidol and [18F]spiroperidol in both no-carrier-added and carrier-added forms have been accomplished. The no-carrier-added [18F]butyrophenone neuroleptics were prepared in low (less than 2%) yield by acid decomposition of aryl piperidine triazenes. Carrier-added 18F-neuroleptics were prepared in better (5-17%) yields by 18F-for-19F nucleophilic aromatic substitution. The preparation of all synthetic precursors, and procedures for radiolabeling are fully described.Entities:
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Year: 1984 PMID： 6469389 DOI： 10.1016/0020-708x(84)90101-7
Source DB: PubMed Journal: Int J Appl Radiat Isot ISSN： 0020-708X