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Literature DB >> 6469353

Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis).

D M Williams, J Schachter, M H Weiner, B Grubbs.

Abstract

In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived immunoglobulin G and A fractions and immune lavage fluid fractions containing immunoglobulins G and A were effective in producing protection when used to opsonize the murine C. trachomatis inoculum. In hyperclean mice (previously made germfree and then colonized with a limited flora nonpathogenic to mice) antibody given intravenously was ineffective. The effects of antibody and nonspecific stimulation of cell-mediated immunity (after previous infection with Histoplasma capsulatum) were additive in increasing host resistance to murine C. trachomatis.

Entities: Disease Species

Mesh：

Substances：
Antibodies, Bacterial

Year: 1984 PMID： 6469353 PMCID： PMC263348 DOI： 10.1128/iai.45.3.674-678.1984

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

18 in total

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18 in total

1. T lymphocyte immunity in host defence against Chlamydia trachomatis and its implication for vaccine development.

Authors: X Yang; R Brunham
Journal: Can J Infect Dis Date: 1998-03

2. Native properdin binds to Chlamydia pneumoniae and promotes complement activation.

Authors: Claudio Cortes; V P Ferreira; Michael K Pangburn
Journal: Infect Immun Date: 2010-12-06 Impact factor: 3.441

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Journal: Infect Immun Date: 1992-06 Impact factor: 3.441

4. Protection of wild-type and severe combined immunodeficiency mice against an intranasal challenge by passive immunization with monoclonal antibodies to the Chlamydia trachomatis mouse pneumonitis major outer membrane protein.

Authors: Sukumar Pal; Jose Bravo; Ellena M Peterson; Luis M de la Maza
Journal: Infect Immun Date: 2008-09-22 Impact factor: 3.441

5. Complement factor C5 but not C3 contributes significantly to hydrosalpinx development in mice infected with Chlamydia muridarum.

Authors: Zhangsheng Yang; Turner Conrad; Zhou Zhou; Jianlin Chen; Pavel Dutow; Andreas Klos; Guangming Zhong
Journal: Infect Immun Date: 2014-05-19 Impact factor: 3.441

6. Divergent outcomes following transcytosis of IgG targeting intracellular and extracellular chlamydial antigens.

Authors: Charles W Armitage; Connor P O'Meara; Marina C G Harvie; Peter Timms; Richard S Blumberg; Kenneth W Beagley
Journal: Immunol Cell Biol Date: 2014-01-21 Impact factor: 5.126

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