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Literature DB >> 6469282

Biliary transport of serum IgA in sheep.

Abstract

The existence of a hepato-biliary pump for IgA has been studied in sheep by measuring appearance of radioactivity in bile after simultaneous i.v. injection of IgG2 and homologous dimeric IgA each labelled with either 125I or 131I. These experiments confirm that in sheep, as in rodents, IgA is the predominant immunoglobulin in bile and is selectively transported into bile from serum relative to IgG2. In addition, there is evidence for local production of IgA in bile presumably by plasma cells within the liver and biliary tree.

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Year: 1984 PMID： 6469282 PMCID： PMC1454715

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

24 in total

1. Occurrence of specific antibodies of the IgA class in the bile of rats.

Authors: J Hall; E Orlans; J Reynolds; C Dean; J Peppard; L Gyure; S Hobbs
Journal: Int Arch Allergy Appl Immunol Date: 1979

2. The origin of the immunoglobulins in intestinal lymph of sheep.

Authors: J W Quin; A J Husband; A K Lascelles
Journal: Aust J Exp Biol Med Sci Date: 1975-06

3. Rat bile as a convenient source of secretory IgA and free secretory component.

Authors: I Lemaître-Coelho; G D Jackson; J P Vaerman
Journal: Eur J Immunol Date: 1977-08 Impact factor: 5.532

4. Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile.

Authors: G D Jackson; I Lemaître-Coelho; J P Vaerman; H Bazin; A Beckers
Journal: Eur J Immunol Date: 1978-02 Impact factor: 5.532

5. The transport by hepatocytes of immunoglobulin A from blood to bile visualized by autoradiography and electron microscopy.

Authors: M S Birbeck; P Cartwright; J G Hall; E Orlans; J Peppard
Journal: Immunology Date: 1979-06 Impact factor: 7.397

Biliary transport of serum IgA in sheep.

1. Occurrence of specific antibodies of the IgA class in the bile of rats.

2. The origin of the immunoglobulins in intestinal lymph of sheep.

3. Rat bile as a convenient source of secretory IgA and free secretory component.

4. Rapid disappearance from serum of intravenously injected rat myeloma IgA and its secretion into bile.

5. The transport by hepatocytes of immunoglobulin A from blood to bile visualized by autoradiography and electron microscopy.

6. The mechanism of transfer of immunoglobulin into mammary secretion of cows.

7. Immunoglobulin-containing cells and the origin of immunoglobulins in the respiratory tract of sheep.

Review 8. Localized humoral immunity with particular reference to ruminants.

9. Human secretory immunoglobulin M. An immunochemical and immunohistochemical study.

10. Rapid active transport of immunoglobulin A from blood to bile.

1. The effect of lactation on the transport of serum-derived IgA into bile of sheep.