Literature DB >> 6468762

Specification of male development in Caenorhabditis elegans: the fem genes.

J Kimble, L Edgar, D Hirsh.   

Abstract

Mutation of the gene fem-2 causes feminization of both sexes: hermaphrodites make no sperm, and males produce oocytes in an intersexual somatic gonad. A double mutant harboring ts alleles of both fem-1 (formerly named isx-1; G. A. Nelson, K. K. Lew, and S. Ward, 1978, Dev. Biol. 66, 386-409) and fem-2 causes transformation of XO animals (normally male) into spermless hermaphrodites at restrictive temperature. The phenotypes, temperature-sensitive periods, and maternal effects observed in mutants of each fem gene are found to be similar. It is suggested that the fem genes are centrally involved in specification of male development in Caenorhabditis elegans--both in the germ line of hermaphrodites and in somatic and germ line tissues of males.

Entities:  

Mesh：

Year:  1984        PMID： 6468762     DOI： 10.1016/0012-1606(84)90279-3

Source DB:  PubMed          Journal:  Dev Biol        ISSN： 0012-1606            Impact factor:   3.582


  38 in total

1.  Somatic sex determination in Caenorhabditis elegans is modulated by SUP-26 repression of tra-2 translation.

Authors:  James Mapes; Jeng-Ting Chen; Jau-Song Yu; Ding Xue
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-04       Impact factor: 11.205

2.  KLP-18, a Klp2 kinesin, is required for assembly of acentrosomal meiotic spindles in Caenorhabditis elegans.

Authors:  Christoph Segbert; Rosemarie Barkus; Jim Powers; Susan Strome; William M Saxton; Olaf Bossinger
Journal:  Mol Biol Cell       Date:  2003-08-22       Impact factor: 4.138

3.  Developmental expression of FOG-1/CPEB protein and its control in the Caenorhabditis elegans hermaphrodite germ line.

Authors:  Liana B Lamont; Judith Kimble
Journal:  Dev Dyn       Date:  2007-03       Impact factor: 3.780

4.  Multiple functions and dynamic activation of MPK-1 extracellular signal-regulated kinase signaling in Caenorhabditis elegans germline development.

Authors:  Min-Ho Lee; Mitsue Ohmachi; Swathi Arur; Sudhir Nayak; Ross Francis; Diane Church; Eric Lambie; Tim Schedl
Journal:  Genetics       Date:  2007-12       Impact factor: 4.562

5.  RNA as a target of double-stranded RNA-mediated genetic interference in Caenorhabditis elegans.

Authors:  M K Montgomery; S Xu; A Fire
Journal:  Proc Natl Acad Sci U S A       Date:  1998-12-22       Impact factor: 11.205

Review 6.  RNA and sex determination in Caenorhabditis elegans. Post-transcriptional regulation of the sex-determining tra-2 and fem-3 mRNAs in the Caenorhabditis elegans hermaphrodite.

Authors:  A Puoti; P Pugnale; M Belfiore; A C Schläppi; Z Saudan
Journal:  EMBO Rep       Date:  2001-10       Impact factor: 8.807

7.  Insertion of the beta Geo promoter trap into the Fem1c gene of ROSA3 mice.

Authors:  Cassandra L Schlamp; Andrew T Thliveris; Yan Li; Louis P Kohl; Claudia Knop; Joel A Dietz; Inna V Larsen; Pascal Imesch; Lawrence H Pinto; Robert W Nickells
Journal:  Mol Cell Biol       Date:  2004-05       Impact factor: 4.272

8.  Mouse Fem1b interacts with the Nkx3.1 homeoprotein and is required for proper male secondary sexual development.

Authors:  Xi Wang; Nishita Desai; Ya-Ping Hu; Sandy M Price; Cory Abate-Shen; Michael M Shen
Journal:  Dev Dyn       Date:  2008-10       Impact factor: 3.780

9.  C. elegans RNA-binding proteins PUF-8 and MEX-3 function redundantly to promote germline stem cell mitosis.

Authors:  Mohd Ariz; Rana Mainpal; Kuppuswamy Subramaniam
Journal:  Dev Biol       Date:  2008-12-07       Impact factor: 3.582

10.  The DEAD-box protein MEL-46 is required in the germ line of the nematode Caenorhabditis elegans.

Authors:  Ryuji Minasaki; Alessandro Puoti; Adrian Streit
Journal:  BMC Dev Biol       Date:  2009-06-17       Impact factor: 1.978
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