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Literature DB >> 6468727

Intracellular localization and characterization of 3-hydroxykynureninase in human liver.

Abstract

3-hydroxykynureninase in human liver was present in cytosol and mitochondria. The cytosolic enzyme and mitochondrial enzyme had the same physiological and enzymic properties. The enzyme had a mol. wt of 130,000 by gel filtration and isoelectric point of pH 5.9. The enzyme was active for 3-hydroxykynurenine and kynurenine, and its activity ratio was 15:1. The apparent Km values of the enzyme were 7.7 X 10(-5) M for 3-hydroxykynurenine, 1.0 X 10(-3) M for kynurenine and 2.5 X 10(-6) M for pyridoxal 5'-phosphate with 3-hydroxykynurenine. Some other properties of purified enzymes are described.

Entities: Chemical Gene Species

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Year: 1984 PMID： 6468727 DOI： 10.1016/0020-711x(84)90031-4

Source DB: PubMed Journal: Int J Biochem ISSN： 0020-711X

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Cited

7 in total

1. An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.

Authors: S J Pearson; A Meldrum; G P Reynolds
Journal: J Neural Transm Gen Sect Date: 1995

5. Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion.

Authors: Abdulla A-B Badawy; Donald M Dougherty
Journal: Int J Tryptophan Res Date: 2016-08-10

6. Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD⁺/NADH ratio.

Authors: Rolf K Berge; Daniel Cacabelos; Rosa Señarís; Jan Erik Nordrehaug; Ottar Nygård; Jon Skorve; Bodil Bjørndal
Journal: Lipids Health Dis Date: 2020-05-14 Impact factor: 3.876

7. Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.

Authors: Abdulla A-B Badawy
Journal: Biosci Rep Date: 2021-07-30 Impact factor: 3.840

7 in total

Intracellular localization and characterization of 3-hydroxykynureninase in human liver.

1. An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.

2. Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine.

Review 3. Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects.

4. Effects of Various Kynurenine Metabolites on Respiratory Parameters of Rat Brain, Liver and Heart Mitochondria.

5. Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion.

6. Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD⁺/NADH ratio.

7. Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.

Intracellular localization and characterization of 3-hydroxykynureninase in human liver.

1. An investigation of the activities of 3-hydroxykynureninase and kynurenine aminotransferase in the brain in Huntington's disease.

2. Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine.

Review 3. Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects.

4. Effects of Various Kynurenine Metabolites on Respiratory Parameters of Rat Brain, Liver and Heart Mitochondria.

5. Assessment of the Human Kynurenine Pathway: Comparisons and Clinical Implications of Ethnic and Gender Differences in Plasma Tryptophan, Kynurenine Metabolites, and Enzyme Expressions at Baseline and After Acute Tryptophan Loading and Depletion.

6. Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD+/NADH ratio.

7. Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria.

6. Hepatic steatosis induced in C57BL/6 mice by a non-ß oxidizable fatty acid analogue is associated with reduced plasma kynurenine metabolites and a modified hepatic NAD⁺/NADH ratio.