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Literature DB >> 6468626

Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship.

Abstract

Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1984 PMID： 6468626 DOI： 10.1007/bf01946464

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

14 in total

1. The distribution and metabolism of acrylamide and its neurotoxic analogues in rats.

Authors: P M Edwards
Journal: Biochem Pharmacol Date: 1975-07-15 Impact factor: 5.858

Review 2. A review of acrylamide neurotoxicity. Part I. Properties, uses and human exposure.

Authors: P S Spencer; H H Schaumburg
Journal: Can J Neurol Sci Date: 1974-05 Impact factor: 2.104

3. Studies on the biochemical basis of distal axonopathies--I. Inhibition of glycolysis by neurotoxic hexacarbon compounds.

Authors: M I Sabri; C L Moore; P S Spencer
Journal: J Neurochem Date: 1979-03 Impact factor: 5.372

4. The etiology of acrylamide neuropathy: enolase, phosphofructokinase, and glyceraldehyde-3-phosphate dehydrogenase activities in peripheral nerve, spinal cord, brain, and skeletal muscle of acrylamide-intoxicated cats.

Authors: R D Howland
Journal: Toxicol Appl Pharmacol Date: 1981-09-15 Impact factor: 4.219

5. Neurotoxicity of acrylamide and related compounds and their effects on male gonads in mice.

Authors: K Hashimoto; J Sakamoto; H Tanii
Journal: Arch Toxicol Date: 1981-06 Impact factor: 5.153

6. Structure-toxicity relationship of acrylates and methacrylates.

Authors: H Tanii; K Hashimoto
Journal: Toxicol Lett Date: 1982-04 Impact factor: 4.372

7. Neurotoxicity of acrylamide and related compounds in rats. Effects on rotarod performance, morphology of nerves and neurotubulin.

Authors: H Tanii; K Hashimoto
Journal: Arch Toxicol Date: 1983-11 Impact factor: 5.153

8. Neuron-specific enolase in relation to differentiation in human neuroblastoma.

Authors: L Odelstad; S Påhlman; K Nilsson; E Larsson; G Läckgren; K E Johansson; S Hjertén; G Grotte
Journal: Brain Res Date: 1981-11-09 Impact factor: 3.252

9. Activity of neuron-specific enolase in normal and lesioned rat brain.

Authors: A Francis; A J Rivett; J A Roth
Journal: Brain Res Date: 1983-03-14 Impact factor: 3.252

10. Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies?

Authors: P S Spencer; M I Sabri; H H Schaumburg; C L Moore
Journal: Ann Neurol Date: 1979-06 Impact factor: 10.422

7 in total

1. Structure-toxicity relationship of ethylene glycol ethers.

Authors: H Tanii; S Saito; K Hashimoto
Journal: Arch Toxicol Date: 1992 Impact factor: 5.153

2. In vivo inactivation of transglutaminase during the acute acrylamide toxic syndrome in the rat.

Authors: C M Bergamini; M Signorini
Journal: Experientia Date: 1990-03-15

3. Neurofilament degradation in the nervous system of rats intoxicated with acrylamide, related compounds or 2,5-hexanedione.

Authors: H Tanii; M Hayashi; K Hashimoto
Journal: Arch Toxicol Date: 1988-08 Impact factor: 5.153