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Literature DB >> 6468589

Noninvolvement of a rat intestinal folate binding protein in physiological folate absorption.

Abstract

Folic acid and its derivatives are observed to be instantaneously bound to rat intestinal mucosal cell curface binding protein. Various parameters were measured such as the optimal pH for binding (6.5), the saturation kinetics observed for folate binding and the avid affinity with which polyglutamyl folates are preferentially bound to the binder. A comparison of the observed results with the conditions reported as favorable for intestinal folate absorption in the rat precludes the involvement of this folate-binding protein in the physiological absorption of folates.

Entities: Chemical Species

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Year: 1984 PMID： 6468589 DOI： 10.1007/bf01951976

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

15 in total

1. Isolation of the folate-binding protein from cow's milk by the use of affinity chromatography.

Authors: D N. Salter; J E. Ford; K J. Scott; P Andrews
Journal: FEBS Lett Date: 1972-02-15 Impact factor: 4.124

2. The purification and characterization of the low molecular weight human folate binding protein using affinity chromatography.

Authors: S Waxman; C Schreiber
Journal: Biochemistry Date: 1975-12-16 Impact factor: 3.162

1. Transport of pteroylglutamic acid into brush border membrane vesicles from rat small intestine is a partially carrier-mediated process.

Authors: A Hahn; H Daniel; G Rehner
Journal: Z Ernahrungswiss Date: 1991-09

2. Evidence for the induction and release of pancreatic folylpolyglutamate hydrolase by the ingestion of folyl polyglutamates in the rat.

Authors: V Kesavan; J M Noronha
Journal: Experientia Date: 1992-09-15

2 in total

Noninvolvement of a rat intestinal folate binding protein in physiological folate absorption.

1. Isolation of the folate-binding protein from cow's milk by the use of affinity chromatography.

2. The purification and characterization of the low molecular weight human folate binding protein using affinity chromatography.

3. Purification of folate binding factor in normal umbilical cord serum.

4. Demonstration of high-affinity folate binding activity associated with the brush border membranes of rat kidney.

Review 5. Acid microclimate in intestinal absorption.

6. Folate binding by the brush border membrane proteins of small intestinal epithelial cells.

7. The folate binding in milk.

8. Partial purification and characterization of a folate-binding protein from human choroid plexus.

9. The role of folic acid binding proteins (FABP) in the cellular uptake of folates.

10. Folate malabsorption in aged rats related to low levels of pancreatic folyl conjugase.

1. Transport of pteroylglutamic acid into brush border membrane vesicles from rat small intestine is a partially carrier-mediated process.

2. Evidence for the induction and release of pancreatic folylpolyglutamate hydrolase by the ingestion of folyl polyglutamates in the rat.