Literature DB >> 6468503

Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol.

D N Middlemiss.   

Abstract

(-)-Propranolol displaced 5-HT1 and 5-HT1B receptor binding (pIC50 6.76 and 6.31 respectively) and antagonized the inhibitory effect of 5-HT on continuous K+ (25 mM) evoked release of [3H]5-HT from superfused rat frontal cortex slices (apparent pA2 6.67). (+)-Propranolol was essentially inactive in all tests. The results support the claim that the 5-HT autoreceptor has a pharmacological resemblance to the 5-HT1 recognition site and in particular to the low affinity 5-HT1B subtype of this site.

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Year:  1984        PMID： 6468503     DOI： 10.1016/0014-2999(84)90173-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  49 in total

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4.  Long-term 5-HT reuptake blockade, but not monoamine oxidase inhibition, decreases the function of terminal 5-HT autoreceptors: an electrophysiological study in the rat brain.

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7.  Prolonged but not acute fluoxetine administration produces its inhibitory effect on hippocampal seizures in rats.

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