Literature DB >> 6467987

In situ hybridization and translocation breakpoint mapping. I. Nonidentical 22q11 breakpoints for the t(9;22) of CML and the t(8;22) of Burkitt lymphoma.

B S Emanuel, J R Selden, E Wang, P C Nowell, C M Croce.   

Abstract

In situ chromosomal hybridization of a probe for part of the lambda light chain constant region (C lambda) has demonstrated that the 22q11 breakpoints of chronic myelogenous leukemia (CML) t(9;22) and Burkitt lymphoma t(8;22) are not identical. For CML, the breakpoint is distal to the IGLC genes, whereas for Burkitt lymphoma it is proximal. The study provides direct evidence for regional assignment of the IGLC gene cluster to 22q11.

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Year:  1984        PMID： 6467987     DOI： 10.1159/000132044

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  8 in total

1.  Comparative mapping of the human 22q11 chromosomal region and the orthologous region in mice reveals complex changes in gene organization.

Authors:  A Puech; B Saint-Jore; B Funke; D J Gilbert; H Sirotkin; N G Copeland; N A Jenkins; R Kucherlapati; B Morrow; A I Skoultchi
Journal:  Proc Natl Acad Sci U S A       Date:  1997-12-23       Impact factor: 11.205

2.  Chromosomal orientation of the lambda light chain locus: V lambda is proximal to C lambda in 22q11.

Authors:  B S Emanuel; L A Cannizzaro; I Magrath; Y Tsujimoto; P C Nowell; C M Croce
Journal:  Nucleic Acids Res       Date:  1985-01-25       Impact factor: 16.971

3.  Low copy repeats mediate distal chromosome 22q11.2 deletions: sequence analysis predicts breakpoint mechanisms.

Authors:  Tamim H Shaikh; Ronald J O'Connor; Mary Ella Pierpont; James McGrath; April M Hacker; Manjunath Nimmakayalu; Elizabeth Geiger; Beverly S Emanuel; Sulagna C Saitta
Journal:  Genome Res       Date:  2007-03-09       Impact factor: 9.043

Review 4.  Human chromosome 22.

Authors:  J C Kaplan; A Aurias; C Julier; M Prieur; M F Szajnert
Journal:  J Med Genet       Date:  1987-02       Impact factor: 6.318

5.  Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

Authors:  J Erikson; C A Griffin; A ar-Rushdi; M Valtieri; J Hoxie; J Finan; B S Emanuel; G Rovera; P C Nowell; C M Croce
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

6.  Comparison of constitutional and tumor-associated 11;22 translocations: nonidentical breakpoints on chromosomes 11 and 22.

Authors:  C A Griffin; C McKeon; M A Israel; A Gegonne; J Ghysdael; D Stehelin; E C Douglass; A E Green; B S Emanuel
Journal:  Proc Natl Acad Sci U S A       Date:  1986-08       Impact factor: 11.205

7.  A linkage and physical map of chromosome 22, and some applications to gene mapping.

Authors:  C Julier; G M Lathrop; A Reghis; M F Szajnert; J M Lalouel; J C Kaplan
Journal:  Am J Hum Genet       Date:  1988-02       Impact factor: 11.025

8.  Comparative mapping of the constitutional and tumor-associated 11;22 translocations.

Authors:  M Budarf; B Sellinger; C Griffin; B S Emanuel
Journal:  Am J Hum Genet       Date:  1989-07       Impact factor: 11.025
  8 in total

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