Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Volume-regulatory K+ efflux during concentrative uptake of alanine in isolated rat hepatocytes.

Literature DB >> 6466316

Volume-regulatory K+ efflux during concentrative uptake of alanine in isolated rat hepatocytes.

Abstract

Changes in cell volume and 42K+ efflux associated with concentrative alanine uptake were studied in isolated rat hepatocytes suspended in Krebs-Ringer bicarbonate buffer. After addition of 10 mM-alanine, cellular water volume increased by 15% and the rate constant of 42K+ efflux by 250%. Alanine-induced 42K+ efflux was abolished by quinine and was strongly decreased when the cell-volume increase was counteracted by sucrose. The results suggest that K+ efflux during alanine uptake is implicated in a volume-regulatory response.

Entities: Chemical Species

Mesh：

Substances：

Year: 1984 PMID： 6466316 PMCID： PMC1144029 DOI： 10.1042/bj2210265

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

16 in total

1. The regulation of uptake and output of amino acids by rat tissues.

Authors: E Ishikawa
Journal: Adv Enzyme Regul Date: 1976

2. Energization of alanine transport in isolated rat hepatocytes. Electrogenic Na+-alanine co-transport leading to increased K+ permeability.

Authors: L O Kristensen
Journal: J Biol Chem Date: 1980-06-10 Impact factor: 5.157

Review 3. Epithelial cell volume modulation and regulation.

Authors: K R Spring; A C Ericson
Journal: J Membr Biol Date: 1982 Impact factor: 1.843

4. Effects of Na-coupled alanine transport on intracellular K activities and the K conductance of the basolateral membranes of Necturus small intestine.

Authors: E Grasset; P Gunter-Smith; S G Schultz
Journal: J Membr Biol Date: 1983 Impact factor: 1.843

5. Sodium-coupled amino acid and sugar transport by Necturus small intestine. An equivalent electrical circuit analysis of a rheogenic co-transport system.

Authors: P J Gunter-Smith; E Grasset; S G Schultz
Journal: J Membr Biol Date: 1982 Impact factor: 1.843

Review 6. Homocellular regulatory mechanisms in sodium-transporting epithelia: avoidance of extinction by "flush-through".

Authors: S G Schultz
Journal: Am J Physiol Date: 1981-12

8. Sodium-coupled glycine uptake by Ehrlich ascites tumor cells results in an increase in cell volume and plasma membrane channel activities.

Authors: R L Hudson; S G Schultz
Journal: Proc Natl Acad Sci U S A Date: 1988-01 Impact factor: 11.205

9. Water, K+, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver.

Authors: F Lang; T Stehle; D Häussinger
Journal: Pflugers Arch Date: 1989-01 Impact factor: 3.657

10. Redistribution of hepatocyte chloride during L-alanine uptake.

Authors: K Wang; R Wondergem
Journal: J Membr Biol Date: 1993-09 Impact factor: 1.843

Volume-regulatory K+ efflux during concentrative uptake of alanine in isolated rat hepatocytes.

1. The regulation of uptake and output of amino acids by rat tissues.

2. Energization of alanine transport in isolated rat hepatocytes. Electrogenic Na+-alanine co-transport leading to increased K+ permeability.

Review 3. Epithelial cell volume modulation and regulation.

4. Effects of Na-coupled alanine transport on intracellular K activities and the K conductance of the basolateral membranes of Necturus small intestine.

5. Sodium-coupled amino acid and sugar transport by Necturus small intestine. An equivalent electrical circuit analysis of a rheogenic co-transport system.

Review 6. Homocellular regulatory mechanisms in sodium-transporting epithelia: avoidance of extinction by "flush-through".

7. Volume-induced increase of anion permeability in human lymphocytes.

8. Concentrative uptake of alanine in hepatocytes from fed and fasted rats.

9. Effects of quinine and apamin on the calcium-dependent potassium permeability of mammalian hepatocytes and red cells.

10. Volume regulation by human lymphocytes. Role of calcium.

1. Cell swelling inhibits proteolysis in perfused rat liver.

2. Emerging roles for sodium dependent amino acid transport in mesenchymal cells.

3. Properties of a cell volume-sensitive potassium conductance in isolated guinea-pig and rat hepatocytes.

4. Energetics of isolated hepatocyte swelling induced by sodium co-transported amino acids.

5. Effect of potassium on cell volume regulation in renal straight proximal tubules.

6. Separate, Ca2+-activated K+ and Cl- transport pathways in Ehrlich ascites tumor cells.

7. The effect of hypoosmolarity on the electrical properties of Madin Darby canine kidney cells.

8. Sodium-coupled glycine uptake by Ehrlich ascites tumor cells results in an increase in cell volume and plasma membrane channel activities.

9. Water, K+, H+, lactate and glucose fluxes during cell volume regulation in perfused rat liver.

10. Redistribution of hepatocyte chloride during L-alanine uptake.