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Literature DB >> 646630

Abortive infection of influenza virus in Ehrlich ascites tumor cells. Unusual fragility of virus particles.

A G Bukrinskaya, A K Gitelman, V B Martynenko.

Abstract

Noninfectious virus particles were produced in Ehrlich ascites tumor cells infected intraperitoneally with fowl plague virus. The PFU yield of virus per cell was less than 0.1 and the ratio PFU/HA units in the progeny virus was less than 10(3). The virus particles had the same morphology and size as egg-grown virus but were more fragile. They were disrupted by centrifugation through sucrose and caesium chloride gradients, but this disruption was avoided by fixing the particles with formaldehyde before centrifugation. Analysis of polypeptides by SDS-PAGE showed that ascites-grown virus particles contained reduced amounts of matrix protein compared with egg-grown virus.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1978 PMID： 646630 DOI： 10.1007/BF01315278

Source DB: PubMed Journal: Arch Virol ISSN： 0304-8608 Impact factor: 2.574

15 in total

1. Activation of influenza A viruses by trypsin treatment.

Authors: H D Klenk; R Rott; M Orlich; J Blödorn
Journal: Virology Date: 1975-12 Impact factor: 3.616

2. Influenza viral RNA and ribonucleoprotein synthesized in abortive infection.

Authors: A Sugiura
Journal: Virology Date: 1972-02 Impact factor: 3.616

3. Organization of the lipid phase in viral membranes. Effects of independent variation of the lipid and the protein composition.

Authors: F R Landsberger; R W Compans; P W Choppin; J Lenard
Journal: Biochemistry Date: 1973-10-23 Impact factor: 3.162

4. Abortive infection of L cells by fowl plague virus: comparison of RNA and protein synthesis in infected chick and L cells.

Authors: S S Gandhi; H B Bell; D C Burke
Journal: J Gen Virol Date: 1971-12 Impact factor: 3.891

5. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors: U K Laemmli
Journal: Nature Date: 1970-08-15 Impact factor: 49.962

6. Replication of influenza virus at elevated temperatures: production of virus-like particles with reduced matrix protein content.

Authors: A P Kendal; J C Galphin; E L Palmer
Journal: Virology Date: 1977-01 Impact factor: 3.616

Review 1. Pathogenicity of influenza virus.

Authors: C Sweet; H Smith
Journal: Microbiol Rev Date: 1980-06

1 in total

Abortive infection of influenza virus in Ehrlich ascites tumor cells. Unusual fragility of virus particles.

1. Activation of influenza A viruses by trypsin treatment.

2. Influenza viral RNA and ribonucleoprotein synthesized in abortive infection.

3. Organization of the lipid phase in viral membranes. Effects of independent variation of the lipid and the protein composition.

4. Abortive infection of L cells by fowl plague virus: comparison of RNA and protein synthesis in infected chick and L cells.

5. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

6. Replication of influenza virus at elevated temperatures: production of virus-like particles with reduced matrix protein content.

7. Polypeptide synthesis in influenza virus-infected cells.

8. Preparation and properties of antibody directed specifically against the neuraminidase of influenza virus.

9. Abortive infection of L cells by influenza virus: absence of virion RNA synthesis.

10. Nonpermissive infections of mammalian cells: synthesis of inluenza virus genome in HeLa cells.

Review 1. Pathogenicity of influenza virus.