Literature DB >> 6466289

Inherited differences in mouse kidney carnosinase activity.

F L Margolis, M Grillo.   

Abstract

Carnosinase is a peptidase which cleaves B-alanyl-L-histidine (carnosine) and closely related dipeptides. Its activity in kidney cytosol of various mouse strains varies more than 50-fold. The highest activity occurs in random-bred CD-1 and inbred NZB/BINJ mice, while it is barely detectable in BALB/cJ, C57BL/6J, and AU/SsJ among others. Carnosinase is immunologically and enzymologically identical in all high-activity strains. This is the first report of quantitative interstrain differences in carnosinase activity. No other peptidase activity has been reported which exhibits the same strain distribution shown here. In matings and backcrosses between the NZB/BINJ and the BALB/cJ strains, the levels of kidney carnosinase activity in the progeny behave as a classical Mendelian trait.

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Year:  1984        PMID： 6466289     DOI： 10.1007/bf00484515

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  20 in total

1.  Inhibition of aminopeptidase B and leucine aminopeptidase by bestatin and its stereoisomer.

Authors:  H Suda; T Aoyagi; T Takeuchi; H Umezawa
Journal:  Arch Biochem Biophys       Date:  1976-11       Impact factor: 4.013

2.  Homocarnosinase: a hog kidney dipeptidase with a broader specificity than carnosinase.

Authors:  J F Lenney; S C Kan; K Siu; G H Sugiyama
Journal:  Arch Biochem Biophys       Date:  1977-11       Impact factor: 4.013

3.  A patient with a deficiency of serum-carnosinase activity.

Authors:  P J van Heeswijk; J M Trijbels; E D Schretlen; P J van Munster; L A Monnens
Journal:  Acta Paediatr Scand       Date:  1969-11

4.  Two molecular forms of swine kidney carnosinase.

Authors:  A Wołos; K Piekarska; J Glogowski; I Konieczka
Journal:  Int J Biochem       Date:  1978

5.  Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt-2 locus on chromosome 8.

Authors:  T Watanabe; N Ogasawara; H Goto
Journal:  Biochem Genet       Date:  1976-12       Impact factor: 1.890

6.  Carnosinemia. A new metabolic disorder associated with neurologic disease and mental defect.

Authors:  T L Perry; S Hansen; B Tischler; R Bunting; K Berry
Journal:  N Engl J Med       Date:  1967-12-07       Impact factor: 91.245

7.  Purification and characterization of a metallo-endoproteinase from mouse kidney.

Authors:  R J Beynon; J D Shannon; J S Bond
Journal:  Biochem J       Date:  1981-12-01       Impact factor: 3.857

8.  Renal tubular processing of small peptide hormones.

Authors:  F A Carone; D R Peterson; G Flouret
Journal:  J Lab Clin Med       Date:  1982-07

9.  Carnosinase deficiency: a new variant with high residual activity.

Authors:  L D Fleisher; D K Rassin; K Wisniewski; H R Salwen
Journal:  Pediatr Res       Date:  1980-04       Impact factor: 3.756

10.  Purification, characterization and immunocytochemical localization of mouse kidney carnosinase.

Authors:  F L Margolis; M Grillo; N Grannot-Reisfeld; A I Farbman
Journal:  Biochim Biophys Acta       Date:  1983-05-18
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  2 in total

1.  Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.

Authors:  Mohamed A Kamal; Huidi Jiang; Yongjun Hu; Richard F Keep; David E Smith
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-02-18       Impact factor: 3.619

2.  Characterization of human tissue carnosinase.

Authors:  J F Lenney; S C Peppers; C M Kucera-Orallo; R P George
Journal:  Biochem J       Date:  1985-06-15       Impact factor: 3.857
  2 in total

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