Literature DB >> 6465186

Sialic acid content and sialidase activity of polymorphonuclear leucocytes in diabetes mellitus.

S N Chari, N Nath.   

Abstract

The level of sialic acid in the diabetic polymorphonuclear leucocytes was found to be significantly reduced as compared to normal. More pronounced effects were observed with ketoacidotic as compared to nonketoacidotic diabetic polymorphonuclear leucocytes. Activity of sialic acid degrading enzyme, sialidase, was found to be increased with more pronounced effect in the ketotic state. Diabetic patients treated either with intravenous insulin or oral hypoglycemic drugs showed restoration to normalcy in both sialic acid content and sialidase activity. The implications of the result are discussed.

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Year:  1984        PMID： 6465186     DOI： 10.1097/00000441-198407000-00003

Source DB:  PubMed          Journal:  Am J Med Sci        ISSN： 0002-9629            Impact factor:   2.378


  6 in total

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Authors:  Fuhui Huang; Bengao Zhu; Haochen Zhang; Yue Gao; Chunmei Ding; Hong Tan; Jianshu Li
Journal:  Mikrochim Acta       Date:  2019-04-08       Impact factor: 5.833

2.  Total and ganglioside-bound sialic acid content of lymphocytes from non-insulin-dependent diabetic patients.

Authors:  M Gavella; V Lipovac; S Crnek
Journal:  Acta Diabetol Lat       Date:  1990 Oct-Dec

3.  Polymorphonuclear leukocytic sialic acid and sialidase activity in obesity.

Authors:  R K Das; M G Muddeshwar
Journal:  Indian J Clin Biochem       Date:  1997-07

Review 4.  Red blood cell rheology in sepsis.

Authors:  M Piagnerelli; K Zouaoui Boudjeltia; M Vanhaeverbeek; J-L Vincent
Journal:  Intensive Care Med       Date:  2003-06-12       Impact factor: 17.440

5.  Glycosylation failure extends to glycoproteins in gestational diabetes mellitus: evidence from reduced α2-6 sialylation and impaired immunomodulatory activities of pregnancy-related glycodelin-A.

Authors:  Cheuk-Lun Lee; Philip C N Chiu; Poh-Choo Pang; Ivan K Chu; Kai-Fai Lee; Riitta Koistinen; Hannu Koistinen; Markku Seppälä; Howard R Morris; Bérangère Tissot; Maria Panico; Anne Dell; William S B Yeung
Journal:  Diabetes       Date:  2011-02-07       Impact factor: 9.461

6.  Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats.

Authors:  Ramasamy Chandramohan; Settu Saravanan; Leelavinothan Pari
Journal:  Pharm Biol       Date:  2017-12       Impact factor: 3.503
  6 in total

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