[Susceptibility of laboratory animals to the Chandipura and Isfahan viruses].

Pathogenicity and immunogenicity of Chandipura and Isfahan rhabdoviruses for laboratory animals were studied. Both viruses were found to be highly pathogenic for mice by the intracerebral route. Chandipura virus is highly pathogenic for mice of different ages by various routes of inoculation. The surviving animals were found to have antibodies demonstrable in different serological tests (agar gel diffusion and precipitation, complement-fixation, the neutralization test by plaque reduction in chick embryo cell culture). In the animals surviving the infection with Chandipura virus antibody could be found as early as 2 weeks, but after inoculation with Isfahan virus the antibody developed slowly and could be detected only at 4 weeks. Pathogenicity for mice of the T-227 and the prototype Isfahan virus strains differed slightly.