Literature DB >> 6462958

The distribution of imipramine and desipramine in rat brain regions after single and chronic administration of imipramine.

J Szymura-Oleksiak, M Panas, W Chruściel.   

Abstract

The regional distribution of imipramine (IMI) and desipramine (DMI) in rat brain after single and chronic oral administration of IMI was studied. The distribution of IMI and DMI in all examined brain regions was similar, except for hippocampus + septum. After chronic administration of IMI the disappearance of the parent drug and its metabolite was slowing down in all investigated brain regions as well as in the plasma. The accumulation of IMI and DMI after chronic treatment of IMI was significantly higher in plasma than in all examined brain regions.

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Year:  1984        PMID： 6462958

Source DB:  PubMed          Journal:  Pol J Pharmacol Pharm        ISSN： 0301-0244


  2 in total

1.  Acute versus repeated administration of desipramine in rats and mice: relationships between brain concentrations and reduction of immobility in the swimming test.

Authors:  M Poncelet; G Gaudel; S Danti; P Soubrié; P Simon
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

2.  Involvement of norepinephrine neurons in the hypothermia induced by intracerebroventricular administration of 6-hydroxydopamine in mice, evidenced by antidepressants.

Authors:  I Leroux-Nicollet; C Panissaud; J Costentin
Journal:  J Neural Transm       Date:  1988       Impact factor: 3.575
  2 in total

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