Literature DB >> 6462135

A stereochemical investigation of phosphoryl transfer catalysed by phosphoglucomutase by the use of alpha-D-glucose 1-[(S)-16O,17O,18O]phosphate.

G Lowe, B V Potter.   

Abstract

Rabbit muscle phosphoglucomutase converts alpha-D-glucose 1-[(S)-16O,17O,18O]phosphate into D-glucose 6-[16O,17O,18O]phosphate, which is shown by 31P n.m.r. spectroscopy, after cyclization and methylation, to have the (S)-configuration at the phosphorus atom. Since phosphoglucomutase is known to catalyse phosphoryl transfer by way of a phospho-enzyme intermediate, and since individual phosphoryl-transfer steps appear in general to occur with inversion of configuration, this observation is most simply interpreted in terms of a double-displacement mechanism with two phosphoryl-transfer steps.

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Year:  1981        PMID： 6462135      PMCID： PMC1163426          DOI： 10.1042/bj1990693

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  A KINETIC STUDY OF THE PHOSPHOGLUCOMUTASE PATHWAY.

Authors:  W J RAY; G A ROSCELLI
Journal:  J Biol Chem       Date:  1964-04       Impact factor: 5.157

2.  Equilibrium constants of phosphoryl transfer from C-1 to C-6 of alpha-D-glucose 1-phosphate and from glucose 6-phosphate to water.

Authors:  M R ATKINSON; E JOHNSON; R K MORTON
Journal:  Biochem J       Date:  1961-04       Impact factor: 3.857

3.  An amino acid sequence in the active centre of phosphoglucomutase.

Authors:  C MILSTEIN; F SANGER
Journal:  Biochem J       Date:  1961-06       Impact factor: 3.857

4.  The occurrence of a group transfer involving enzyme (phosphoglucomutase) and substrate.

Authors:  V A NAJJAR; M E PULLMAN
Journal:  Science       Date:  1954-05-07       Impact factor: 47.728

5.  Arrangement of the phosphate-and metal-binding subsites of phosphoglucomutase. Intersubsite distance by means of nuclear magnetic resonance measurements.

Authors:  W J Ray; A S Mildvan
Journal:  Biochemistry       Date:  1973-09-11       Impact factor: 3.162

6.  Arrangement of the phosphate-and metal-binding subsites of phosphoglucomutase. Intersubsite relationships by means of inhibition patterns.

Authors:  W J Ray; A S Mildvan; J W Long
Journal:  Biochemistry       Date:  1973-09-11       Impact factor: 3.162

7.  The mechanism of the phosphoglucomutase reaction. Studies on rabbit muscle phosphoglucomutase with flux techniques.

Authors:  H G Britton; J B Clarke
Journal:  Biochem J       Date:  1968-11       Impact factor: 3.857

Review 8.  Enzyme-catalyzed phosphoryl transfer reactions.

Authors:  J R Knowles
Journal:  Annu Rev Biochem       Date:  1980       Impact factor: 23.643

9.  Phosphoglycerate mutases: stereochemical course of the phosphoryl group transfers catalyzed by the cofactor-dependent enzyme from rabbit muscle and the cofactor-independent enzyme from wheat germ.

Authors:  W A Blättler; J R Knowles
Journal:  Biochemistry       Date:  1980-02-19       Impact factor: 3.162

Review 10.  Stereochemistry of phosphoryl transfer.

Authors:  G Lowe; P M Cullis; R L Jarvest; B V Potter; B S Sproat
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  1981-06-26       Impact factor: 6.237
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  2 in total

1.  Mechanistic Insights on Human Phosphoglucomutase Revealed by Transition Path Sampling and Molecular Dynamics Calculations.

Authors:  Natércia F Brás; Pedro A Fernandes; Maria J Ramos; Steven D Schwartz
Journal:  Chemistry       Date:  2018-01-04       Impact factor: 5.236

2.  Mechanism of action of rabbit liver phosphoglucomutase.

Authors:  H Jamil; J B Clarke
Journal:  Biochem J       Date:  1985-09-15       Impact factor: 3.857
  2 in total

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