Literature DB >> 6461764

1-Acyltriazoles as antiinflammatory agents.

P C Wade, B R Vogt, T P Kissick, L M Simpkins, D M Palmer, R C Millonig.   

Abstract

Certain 1-acyl-3-phenyl-5-alkyltriazoles were synthesized and evaluated for antiinflammatory activity using the mouse active Arthus (MAA) reaction as the test system. Modification of the acyl group, 4-phenyl substituent, and alkyl group led to the selection of the most active member of this series, 1-acetyl-3-(4-chlorophenyl)-5-methyl-1,2,4-triazole (3c), for further evaluation as a novel nonacidic antiinflammatory agent.

Entities:  

Mesh：

Substances：

Year:  1982        PMID： 6461764     DOI： 10.1021/jm00345a021

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  3 in total

1.  Parallel synthesis of 1,2,4-triazole derivatives using microwave and continuous-flow techniques.

Authors:  Tamás Szommer; András Lukács; József Kovács; Miklós J Szabó; Michael G Hoffmann; Monika H Schmitt; János Gerencsér
Journal:  Mol Divers       Date:  2012-01-26       Impact factor: 2.943

2.  Synthesis of new bis-1,2,4-triazole derivatives.

Authors:  Olcay Bekircan; Hakan Bektas
Journal:  Molecules       Date:  2006-06-21       Impact factor: 4.411

3.  Synthesis, antimicrobial, and anti-inflammatory activity, of novel S-substituted and N-substituted 5-(1-adamantyl)-1,2,4-triazole-3-thiols.

Authors:  Ebtehal S Al-Abdullah; Hanadi H Asiri; Siham Lahsasni; Elsayed E Habib; Tarek M Ibrahim; Ali A El-Emam
Journal:  Drug Des Devel Ther       Date:  2014-05-12       Impact factor: 4.162
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.