Literature DB >> 6459754

Non-disjunction in trisomy 21: study of chromosomal heteromorphisms in 110 families.

M Mikkelsen, H Poulsen, J Grinsted, A Lange.   

Abstract

QM variants on chromosome 21 and silver staining of NOR regions were applied in the study of non-disjunction in 110 families from different parts of Denmark. In 76% of the families the study was informative. Paternal failures were observed in 11% on Funen as compared 23.5% on Zealand. In one family, crossing-over on the short arms of chromosome 21 in the mother and mitotic non-disjunction of chromosome 21 was observed. Maternal first meiotic error predominates in both high maternal and low maternal age. Also in paternal non-disjunction failures of first meiotic division predominate. Two maternally and one paternally originated cases of de novo translocations were observed.

Entities:  

Mesh：

Year:  1980        PMID： 6459754     DOI： 10.1111/j.1469-1809.1980.tb00942.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN： 0003-4800            Impact factor:   1.670


  37 in total

1.  Comparative study of microsatellite and cytogenetic markers for detecting the origin of the nondisjoined chromosome 21 in Down syndrome.

Authors:  M B Peterson; M Frantzen; S E Antonarakis; A C Warren; C Van Broeckhoven; A Chakravarti; T K Cox; C Lund; B Olsen; H Poulsen
Journal:  Am J Hum Genet       Date:  1992-09       Impact factor: 11.025

2.  Oocyte selection: a new model for the maternal-age dependence of Down syndrome.

Authors:  C J Zheng; B Byers
Journal:  Hum Genet       Date:  1992 Sep-Oct       Impact factor: 4.132

3.  Parental age and the origin of trisomy 21. A study of 302 families.

Authors:  F Dagna Bricarelli; M Pierluigi; M Landucci; A Arslanian; D A Coviello; M A Ferro; P Strigini
Journal:  Hum Genet       Date:  1989-04       Impact factor: 4.132

4.  A molecular genetic approach to the identification of isochromosomes of chromosome 21.

Authors:  L G Shaffer; C K Jackson-Cook; J M Meyer; J A Brown; J E Spence
Journal:  Hum Genet       Date:  1991-02       Impact factor: 4.132

5.  Use of short sequence repeat DNA polymorphisms after PCR amplification to detect the parental origin of the additional chromosome 21 in Down syndrome.

Authors:  M B Petersen; A A Schinzel; F Binkert; L Tranebjaerg; M Mikkelsen; F A Collins; E P Economou; S E Antonarakis
Journal:  Am J Hum Genet       Date:  1991-01       Impact factor: 11.025

6.  Paternal age and trisomy among spontaneous abortions.

Authors:  M Hatch; J Kline; B Levin; M Hutzler; D Warburton
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

7.  Frequency and distribution of aneuploidy in human female gametes.

Authors:  F Pellestor
Journal:  Hum Genet       Date:  1991-01       Impact factor: 4.132

8.  The prophase stages in human foetal oocytes studied by light and electron microscopy.

Authors:  R M Speed
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

9.  Isolation of chromosome-21-specific DNA probes and their use in the analysis of nondisjunction in Down syndrome.

Authors:  J Galt; E Boyd; J M Connor; M A Ferguson-Smith
Journal:  Hum Genet       Date:  1989-01       Impact factor: 4.132

Review 10.  The embryology of conjoined twins.

Authors:  M H Kaufman
Journal:  Childs Nerv Syst       Date:  2004-07-27       Impact factor: 1.475
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