Qualitative changes in saliva composition after short-term administration of imipramine and zimelidine in healthy volunteers.

Ten healthy volunteers participated in a double-blind controlled, randomized, cross-over trial, where the effects of the antidepressant drugs imipramine (75 mg/day) and zimelidine (100 mg/day and 200 mg/day) on saliva secretion rate and saliva composition were tested. The saliva secretion decreased and qualitative changes were found. Imipramine (75 mg/day) and zimelidine (200 mg/day), but not zimelidine (100 mg/day), increased buffer capacity and the components of the salivary glycoproteins (sialic acid, fucose, hexoses). Total proteins, amylase, secretory component and electrolytes (Na+, K+, Ca++, PO43-) did not change significantly.

RCT Entities:   Population Interventions Outcomes