Literature DB >> 6458424

Autoimmune thyroiditis: a condition related to a decrease in T-suppressor cells.

C Thielemans, L Vanhaelst, M de Waele, M Jonckheer, B Van Camp.   

Abstract

Monoclonal antibodies recognizing specific antigenic determinants of peripheral T-lymphocytes (OKT3PAN), helper T-cells (OKT4IND) and suppressor T-cells (OKT8SUP) were used to study the immune regulation in autoimmune thyroiditis. An indirect immunofluorescence microscopy method was employed to quantify the number of different subtypes. In addition, B-lymphocytes were also studied using a fluorescent surface Ig detection technique. Patients with autoimmune thyroiditis--independent of their clinical status--show a decrease in the number of suppressor T-lymphocytes. This finding, in agreement with other functional tests, indicates that the autoimmune phenomenon is linked to a decreased T-suppressor activity.

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Year:  1981        PMID： 6458424     DOI： 10.1111/j.1365-2265.1981.tb00664.x

Source DB:  PubMed          Journal:  Clin Endocrinol (Oxf)        ISSN： 0300-0664            Impact factor:   3.478


  19 in total

1.  Immunological studies on Crohn's disease. V. Enumeration of circulating lymphocytes subsets using monoclonal antibodies.

Authors:  N Okabe; K Fujita; M Yamasaki; T Yao; S Tsuru
Journal:  Gastroenterol Jpn       Date:  1985-10

2.  Induction of in vitro autoimmune responses by mononuclear blood cells in Hashimoto's thyroiditis.

Authors:  S A Stern; P C Dau
Journal:  Clin Exp Immunol       Date:  1987-09       Impact factor: 4.330

3.  Immunohistological phenotyping of thyroid infiltrating lymphocytes in Graves' disease and Hashimoto's thyroiditis.

Authors:  T Misaki; J Konishi; T Nakashima; Y Iida; K Kasagi; K Endo; T Uchiyama; K Kuma; K Torizuka
Journal:  Clin Exp Immunol       Date:  1985-04       Impact factor: 4.330

Review 4.  Polyglandular autoimmune syndrome: current concepts.

Authors:  J Meyerson; E E Lechuga-Gomez; P E Bigazzi; P G Walfish
Journal:  CMAJ       Date:  1988-04-01       Impact factor: 8.262

5.  Decreased T-suppressor cell activity in rats with adjuvant arthritis.

Authors:  L Binderup
Journal:  Ann Rheum Dis       Date:  1983-12       Impact factor: 19.103

6.  Biological activity of lymphocytotoxic antibodies in Graves' disease and Hashimoto's thyroiditis.

Authors:  W Pruzanski; H Capes; R Baur; B E Wenzel; V V Row; R Volpé
Journal:  J Endocrinol Invest       Date:  1984-02       Impact factor: 4.256

7.  Autoimmune thyroiditis.

Authors:  M H De Baets
Journal:  Surv Immunol Res       Date:  1983

8.  Analysis of T cell subsets in Graves' disease: alterations associated with carbimazole.

Authors:  M E Ludgate; A M McGregor; A P Weetman; S Ratanachaiyavong; J H Lazarus; R Hall; G W Middleton
Journal:  Br Med J (Clin Res Ed)       Date:  1984-02-18

9.  Alterations in immune cell subsets and their cytokine secretion profile in childhood idiopathic thrombocytopenic purpura (ITP).

Authors:  R M Talaat; A M Elmaghraby; S S Barakat; M El-Shahat
Journal:  Clin Exp Immunol       Date:  2014-05       Impact factor: 4.330

10.  Effect of carbimazole treatment on specific and non-specific immunological parameters in patients with Graves' disease.

Authors:  J Charreire; G Karsenty; P Bouchard; G Schaison
Journal:  Clin Exp Immunol       Date:  1984-09       Impact factor: 4.330
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