Literature DB >> 6457152

Effect of inhaled alpha-blocker on airflow obstruction in asthma.

J Britton, J Ayres, G M Cochrane.   

Abstract

A controlled study of the effect on airflow obstruction of 30 mg of the alpha-blocker thymoxamine given by inhalation is reported in 10 patients with chronic stable asthma. No significant change in peak expiratory flow rate was seen with either thymoxamine or placebo in any patient. Alpha-adrenergic receptors are therefore unlikely to contribute significantly to resting bronchomotor tone in chronic stable asthma.

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Year:  1981        PMID： 6457152      PMCID： PMC1438857          DOI： 10.1177/014107688107400904

Source DB:  PubMed          Journal:  J R Soc Med        ISSN： 0141-0768            Impact factor:   18.000


  11 in total

1.  Alpha-adrenergic hyper-responsiveness in asthma.

Authors:  W R Henderson; J H Shelhamer; D B Reingold; L J Smith; R Evans; M Kaliner
Journal:  N Engl J Med       Date:  1979-03-22       Impact factor: 91.245

2.  The effect of alpha-adrenoreceptor stimulation on the airways of normal and asthmatic man.

Authors:  P D Snashall; F A Boother; G M Sterling
Journal:  Clin Sci Mol Med       Date:  1978-03

3.  Alpha-adrenergic receptors in human and canine tracheal and bronchial smooth muscle.

Authors:  M P Kneussl; J B Richardson
Journal:  J Appl Physiol Respir Environ Exerc Physiol       Date:  1978-08

4.  In vivo and in vitro studies on alpha-receptors in human airways. Potentiation with bacterial endotoxin.

Authors:  B G Simonsson; N Svedmyr; B E Skoogh; R Andersson; N P Bergh
Journal:  Scand J Respir Dis       Date:  1972

5.  The effect of an alpha-adrenergic receptor blocking drug on histamine sensitivity in bronchial asthma.

Authors:  J Gaddie; J S Legge; G Petrie; K N Palmer
Journal:  Br J Dis Chest       Date:  1972-04

6.  The effect of thymoxamine on histamine induced bronchospasm in man.

Authors:  S Bianco; J P Griffin; P L Kamburoff; F J Prime
Journal:  Br J Dis Chest       Date:  1972-01

7.  Exercise-induced bronchospasm: effect of adrenergic or cholinergic blockade.

Authors:  R M Sly; E M Heimlich; R J Busser; L Strick
Journal:  J Allergy       Date:  1967-08

8.  Plasma catecholamines in exercise induced bronchoconstriction.

Authors:  M Beil; H M Brecht; B Rasche
Journal:  Klin Wochenschr       Date:  1977-06-15

9.  The effect of thymoxamine and cromolyn sodium on postexercise bronchoconstriction in asthma.

Authors:  K R Patel; J W Kerr; E B MacDonald; A M MacKenzie
Journal:  J Allergy Clin Immunol       Date:  1976-04       Impact factor: 10.793

Review 10.  The role of adrenoceptors in bronchial asthma.

Authors:  K R Patel
Journal:  J R Coll Physicians Lond       Date:  1979-07
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  1 in total

1.  Prazosin in the treatment of chronic asthma.

Authors:  S V Baudouin; T J Aitman; A J Johnson
Journal:  Thorax       Date:  1988-05       Impact factor: 9.139
  1 in total

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