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Literature DB >> 6456986

Demonstration of a new genetic locus in the major histocompatibility system of the rat.

Abstract

A new recombination within the major histocompatibility complex (RT1) of the rat has been detected. The recombination occurred between a wild-derived haplotype, provisionally designated p1, and the RT1 haplotype of the BN strain. The recombinant haplotype, designated p3, carries the RT1. A locus (classical histocompatibility antigens) of the BN strain, a locus from the BN strain that codes for the expression of an Ia antigen and strong mixed lymphocyte response (MLR), and a second locus derived from the p1 haplotype that controls the expression of a second Ia antigen, the ability to elicit a strong MLR and the immune response to poly(Glu52Lys33Tyr15). This recombinant therefore demonstrates the division of the RT1.B region into two loci, tentatively designated RT1.B and RT1.D, and provides evidence for the existence of at least four loci in the MHC of the rat.

Entities: Chemical Gene Species

Mesh：

Year: 1981 PMID： 6456986 DOI： 10.1007/bf00343714

Source DB: PubMed Journal: Immunogenetics ISSN： 0093-7711 Impact factor: 2.846

12 in total

1. The association of immune responsiveness, mixed lymphocyte responses, and Ia antigens in natural populations of Norway rats.

Authors: J W Shonnard; B K Davis; D V Cramer; S F Radka; T J Gill
Journal: J Immunol Date: 1979-08 Impact factor: 5.422

2. Ia antigens in inbred rats and their relationship to the MLR phenotype.

Authors: S F Radka; D V Cramer; T J Gill
Journal: J Immunol Date: 1977-12 Impact factor: 5.422

3. Quantitative micro-method for measuring antibody utilizing the bromoacetyl cellulose immunoadsorbant.

Authors: T J Gill; C F Bernard
Journal: Immunochemistry Date: 1969-07

Review 4. Hybrid I region antigens.

Authors: C G Fathman
Journal: Transplantation Date: 1980-07 Impact factor: 4.939

5. The LEW.BN(2R) strain: a recombinant in the rat MHC.

Authors: D H Lynch; C W DeWitt
Journal: J Immunol Date: 1980-05 Impact factor: 5.422

6. Sharing of Ia antigens between species. II. Molecular localization of shared Ia determinants implies the existence of more than one I sublocus of the rat MHC.

Authors: N Shinohara; J K Lunney; D H Sachs
Journal: J Immunol Date: 1978-08 Impact factor: 5.422

7. Partial N-terminal amino acid sequence of rat transplantation antigens.

Authors: E P Blankenhorn; J M Cecka; D Goetze; L Hood
Journal: Nature Date: 1978-07-06 Impact factor: 49.962

8. Evidence for homologues of the murine I-A and I-E loci in the rat MHC.

Authors: N Shinohara; D H Sachs
Journal: J Immunol Date: 1981-03 Impact factor: 5.422

9. Genetic definition of a further gene region and identification of at least three different histocompatibility genes in the rat major histocompatibility system.

Authors: M Kohoutavá; E Günther; O Stark
Journal: Immunogenetics Date: 1980 Impact factor: 2.846

Demonstration of a new genetic locus in the major histocompatibility system of the rat.

1. The association of immune responsiveness, mixed lymphocyte responses, and Ia antigens in natural populations of Norway rats.

2. Ia antigens in inbred rats and their relationship to the MLR phenotype.

3. Quantitative micro-method for measuring antibody utilizing the bromoacetyl cellulose immunoadsorbant.

Review 4. Hybrid I region antigens.

5. The LEW.BN(2R) strain: a recombinant in the rat MHC.

6. Sharing of Ia antigens between species. II. Molecular localization of shared Ia determinants implies the existence of more than one I sublocus of the rat MHC.

7. Partial N-terminal amino acid sequence of rat transplantation antigens.

8. Evidence for homologues of the murine I-A and I-E loci in the rat MHC.

9. Genetic definition of a further gene region and identification of at least three different histocompatibility genes in the rat major histocompatibility system.

10. Structure of Ia antigens from the rat. Mouse alloantisera demonstrate at least two distinct molecular species.

1. Genetic control of rat heart allograft rejection: effect of different MHC and non-MHC incompatibilities.

2. Reactivity of normal rat epiphyseal chondrocytes with monoclonal antibodies recognizing different leucocyte markers.

3. Orientation of the loci encoding RT1.B polypeptides in the major histocompatibility complex of the rat.

4. Characterization of the Ia antigens involved in suppressor T cell generation in the rat.

5. Polymorphism and mapping of the class II genes in the rat: RT1.B, RT1.D, and RT1.H, a new DP-like region.

6. The RT1.B/D-region products defined by rat monoclonal alloantibodies.

Review 7. The immunology of experimental liver transplantation in the rat.

8. CML characterization of a product of a second class I locus in the rat MHC.

Review 9. Major histocompatibility complex of the rat.

10. Cim: an MHC class II-linked allelism affecting the antigenicity of a classical class I molecule for T lymphocytes.