Literature DB >> 6455174

Effects of acute administration of ethane hydroxydiphosphonate (EHDP) on skeletal scintigraphy with technetium-99m methylene diphosphonic acid (Tc-MDP) in the rat.

I Watt, P Hill.   

Abstract

A study has been performed in the rat to assess the effect of EHDP on the distribution of 99Tcm-labelled MDP used for skeletal imaging. Profound alterations in bone, kidney and blood levels were observed. These observations cast doubt on the value of bone scans for monitoring the therapeutic effect of diphosphonates.

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Year:  1981        PMID： 6455174     DOI： 10.1259/0007-1285-54-643-592

Source DB:  PubMed          Journal:  Br J Radiol        ISSN： 0007-1285            Impact factor:   3.039


  1 in total

1.  Bone histology at autopsy and matched bone scintigraphy findings in patients with hormone refractory prostate cancer: the effect of bisphosphonate therapy on bone scintigraphy results.

Authors:  M P Roudier; H Vesselle; L D True; C S Higano; S M Ott; S H King; R L Vessella
Journal:  Clin Exp Metastasis       Date:  2003       Impact factor: 5.150
  1 in total

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