| Literature DB >> 645352 |
Abstract
Amphetamine productes protein leakage in the brain when given to rats under nitrous oxide anesthesia. The blood-brain barrier dysfunction is caused by the combined effect of blood pressure increase and vasodilatation. In the present experiments pretreatment with dexamethasone, 2 mg.kg-1, diminished the amphetamine-induced extravasation of Evans blue albumin and 125IHSA in the rats' brain. Possible explanations to the effect of dexamethasone on cerebrovascular permeability are discussed.Entities:
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Year: 1978 PMID： 645352 DOI： 10.1111/j.1600-0404.1978.tb02835.x
Source DB: PubMed Journal: Acta Neurol Scand ISSN： 0001-6314 Impact factor: 3.209