Literature DB >> 6453101

Alkali-labile sites in biologically active DNA: comparison of radiation induced potential breaks and apurinic sites.

M V Lafleur, J Woldhuis, H Loman.   

Abstract

Gamma-ray induced alkali-labile sites, which are converted into breaks by alkali or heat, are compared with apurinic sites in both single-stranded and phi X174RF-DNA. It is shown that the kinetics of the conversion into breaks are completely different for both sites. The conclusion is: the gamma-ray induced alkali-labile sites are not identical with apurinic or/and apyrimidinic sites.

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Year:  1981        PMID: 6453101     DOI: 10.1080/09553008114550131

Source DB:  PubMed          Journal:  Int J Radiat Biol Relat Stud Phys Chem Med        ISSN: 0020-7616


  4 in total

1.  Unpaired bases in phage DNA after gamma-irradiation in-situ and in-vitro.

Authors:  H Martin-Bertram; P Hartl; C Winkler
Journal:  Radiat Environ Biophys       Date:  1984       Impact factor: 1.925

2.  Some characteristics of apurinic sites in single- and double-stranded biologically active phi X174 DNA.

Authors:  M V Lafleur; J Woldhuis; H Loman
Journal:  Nucleic Acids Res       Date:  1981-12-11       Impact factor: 16.971

3.  Mutagenesis by the autoxidation of iron with isolated DNA.

Authors:  L A Loeb; E A James; A M Waltersdorph; S J Klebanoff
Journal:  Proc Natl Acad Sci U S A       Date:  1988-06       Impact factor: 11.205

4.  Post-irradiation chemical processing of DNA damage generates double-strand breaks in cells already engaged in repair.

Authors:  Satyendra K Singh; Minli Wang; Christian Staudt; George Iliakis
Journal:  Nucleic Acids Res       Date:  2011-07-10       Impact factor: 16.971

  4 in total

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