Pigmented penile lesions (fixed drug eruptions) associated with tetracycline therapy for sexually transmitted diseases.

Two men had pigmented penile lesions that were diagnosed as fixed drug eruptions. The lesions developed after ingestion of tetracycline for nongonococcal urethritis and syphilis, respectively. Because use of tetracycline for treatment of sexually transmitted diseases is becoming more common, physicians must be able to recognize the allergic reactions to this drug.