Literature DB >> 6452418

Suppression of activity of mouse natural killer (NK) cells by activated macrophages from mice treated with pyran copolymer.

A Santoni, C Riccardi, T Barlozzari, R B Herberman.   

Abstract

Treatment of young mice with pyran copolymer caused a substantial decrease in natural killer (NK) cell activity at 7 days. The decrease in cytotoxicity was associated with the presence of splenic suppressor cells, capable of inhibiting in vitro the NK activity of spleen cells from normal mice. The suppressor cells appeared to be macrophages, being plastic-adherent, phagocytic and radioresistant, and lacking demonstrable Thy 1.2 antigen. Sonicates or culture supernatants of adherent spleen cells from pyran-treated mice were also able to inhibit NK activity, suggesting that suppressor cells act by release of soluble factors.

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Year:  1980        PMID： 6452418     DOI： 10.1002/ijc.2910260619

Source DB:  PubMed          Journal:  Int J Cancer        ISSN： 0020-7136            Impact factor:   7.396


  10 in total

1.  Deficient natural killer cell activity in alcoholic cirrhosis.

Authors:  B Charpentier; D Franco; L Paci; M Charra; B Martin; D Vuitton; D Fries
Journal:  Clin Exp Immunol       Date:  1984-10       Impact factor: 4.330

2.  In vivo boosting of lung natural killer and lymphokine-activated killer cell activity by interleukin-2: comparison of systemic, intrapleural and inhalation routes.

Authors:  J P Flexman; L S Manning; B W Robinson
Journal:  Clin Exp Immunol       Date:  1990-10       Impact factor: 4.330

3.  FCE20696, a new synthetic immunomodulator: immunopharmacological profile.

Authors:  A M Isetta; M C Fornasiero; M Ferrari; D Trizio
Journal:  Agents Actions       Date:  1989-11

4.  Influence of adoptively transferred thioglycollate-elicited peritoneal macrophages on metastasis formation in mice with depressed or stimulated NK activity.

Authors:  E Gorelik; R H Wiltrout; M J Brunda; W E Bere; R B Herberman
Journal:  Clin Exp Metastasis       Date:  1985 Apr-Jun       Impact factor: 5.150

5.  Inhibition of mouse natural killer activity by cyclosporin A.

Authors:  R H Yanagihara; W H Adler
Journal:  Immunology       Date:  1982-02       Impact factor: 7.397

6.  Development of hyporesponsiveness of natural killer cells to augmentation of activity after multiple treatments with biological response modifiers.

Authors:  T Saito; R Ruffman; R D Welker; R B Herberman; M A Chirigos
Journal:  Cancer Immunol Immunother       Date:  1985       Impact factor: 6.968

7.  High dietary vitamin A (retinyl palmitate) and cellular immune functions in mice.

Authors:  S Moriguchi; L Werner; R R Watson
Journal:  Immunology       Date:  1985-09       Impact factor: 7.397

8.  Suppression of murine NK activity induced by Corynebacterium parvum: further characterization and abrogation of suppressor cells.

Authors:  V K Milisauskas; G Cudkowicz; I Nakamura
Journal:  Cancer Immunol Immunother       Date:  1986       Impact factor: 6.968

9.  Suppression of natural killer cell activity by adherent effusion cells of cancer patients. Suppression of motility, binding capacity and lethal hit of NK cells.

Authors:  A Uchida; M Colot; M Micksche
Journal:  Br J Cancer       Date:  1984-01       Impact factor: 7.640

Review 10.  Biology of natural killer cells.

Authors:  G Trinchieri
Journal:  Adv Immunol       Date:  1989       Impact factor: 3.543
  10 in total

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