Literature DB >> 6452187

Effect of impromidine (SK&F 92676) on the isolated papillary muscle of the guinea-pig.

G Bertaccini, G Coruzzi.   

Abstract

Impromidine was found to have a positive inotropic effect on the isolated papillary muscle from the guinea-pig. The dose-response curve to impromidine was shifted to the right by cimetidine and ranitidine. Impromidine was 35 times more potent than histamine but with a maximal response of only 81% that obtained with histamine. This difference, which was statistically significant (P < 0.005), suggested that impromidine acts as a partial agonist at the histamine H2-receptors of the papillary muscle as has been observed in other tissues.

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Year:  1981        PMID： 6452187      PMCID： PMC2071505          DOI： 10.1111/j.1476-5381.1981.tb09113.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  13 in total

1.  Evidence for the existence of another type of histamine H2-receptor in guinea-pig ileum.

Authors:  B Fjalland
Journal:  J Pharm Pharmacol       Date:  1979-01       Impact factor: 3.765

2.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

3.  Pharmacological activities of 2-(5-methyl-4-imidazolyl)ethylamine.

Authors:  G Bertaccini; M Impicciatore; T Vitali; V Plazzi
Journal:  Farmaco Sci       Date:  1972-08

4.  Effect of histamine and related compounds on the papillary muscle of the guinea pig.

Authors:  G Bertaccini; G Coruzzi; T Vitali
Journal:  Pharmacol Res Commun       Date:  1978-09

5.  Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors.

Authors:  G J Durant; W A Duncan; C R Ganellin; M E Parsons; R C Blakemore; A C Rasmussen
Journal:  Nature       Date:  1978-11-23       Impact factor: 49.962

6.  Histamine receptors in the heart and coronary vessels of rabbits.

Authors:  G Coruzzi; S Bongrani; G Bertaccini
Journal:  Pharmacol Res Commun       Date:  1979-06

7.  Action of histamine receptor agonists and antagonists on the rat uterus.

Authors:  G Bertaccini; E Molina; T Vitali; L Zappia
Journal:  Br J Pharmacol       Date:  1979-05       Impact factor: 8.739

8.  Biological activities of a new specific stimulant of histamine H2 receptors.

Authors:  G Bertaccini; M Impicciatore; T Vitali
Journal:  Farmaco Sci       Date:  1976-12

9.  Analysis of anomalous pKb values for metiamide and atropine in the isolated stomach of the mouse.

Authors:  J A Angus; J W Black
Journal:  Br J Pharmacol       Date:  1979-09       Impact factor: 8.739

10.  Relaxant action of histamine on rabbit trachea: possible existence of third histamine receptor subtype.

Authors:  N Chand; P Eyre; L DeRoth
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1979-02
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  9 in total

1.  In vivo characterization of histamine H1- and H2-receptors in the rat stomach microcirculation.

Authors:  A Koo
Journal:  Br J Pharmacol       Date:  1983-01       Impact factor: 8.739

2.  Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine. Are cell type-specific H2-receptors involved in the regulation of NADPH oxidase?

Authors:  R Burde; A Buschauer; R Seifert
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1990-05       Impact factor: 3.000

Review 3.  The Roles of Cardiovascular H2-Histamine Receptors Under Normal and Pathophysiological Conditions.

Authors:  Joachim Neumann; Uwe Kirchhefer; Stefan Dhein; Britt Hofmann; Ulrich Gergs
Journal:  Front Pharmacol       Date:  2021-12-20       Impact factor: 5.810

4.  Effect of some new Histamine H2-receptor antagonists on the guinea-pig papillary muscle.

Authors:  G Bertaccini; G Coruzzi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-11       Impact factor: 3.000

5.  Cardiac and gastric effects of histamine H2 receptor antagonists: no evidence for a correlation between lipophilicity and receptor affinity.

Authors:  G Coruzzi; M Adami; C Pozzoli; F Giorgi; G Bertaccini
Journal:  Br J Pharmacol       Date:  1996-08       Impact factor: 8.739

6.  Characterization of histamine receptors in isolated human cerebral arteries.

Authors:  A Ottosson; I Jansen; L Edvinsson
Journal:  Br J Pharmacol       Date:  1988-07       Impact factor: 8.739

7.  In vitro cardiac pharmacology of the new histamine H2-receptor agonist amthamine: comparisons with histamine and dimaprit.

Authors:  E Poli; C Pozzoli; G Coruzzi; G Bertaccini; H Timmerman
Journal:  Agents Actions       Date:  1993-09

8.  Effects of impromidine, a specific H2-receptor agonist and 2(2-pyridyl)-ethylamine, an H1-receptor agonist, on stimulation-induced release of [3H]-noradrenaline in guinea-pig isolated atria.

Authors:  M J Rand; D F Story; H Wong-Dusting
Journal:  Br J Pharmacol       Date:  1982-06       Impact factor: 8.739

9.  Impromidine is a partial histamine H2-receptor agonist on human ventricular myocardium.

Authors:  T A English; R W Gristwood; D A Owen; J Wallwork
Journal:  Br J Pharmacol       Date:  1986-10       Impact factor: 8.739
  9 in total

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