Early metabolic alterations during the development of experimentally induced cardiac hypertrophy.

The main biochemical features of protein synthesis in the myocardium are described as well as several metabolic alterations that occur during the very early stages in three models of cardiac hypertrophy resulting from pressure overload in vivo and in vitro, application of a high dose of isoprenaline and repeated daily administration of triiodothyronine. Furthermore, both mechanical and metabolic factors possibly participating in the development of cardiac hypertrophy are discussed and critically evaluated.