| Literature DB >> 6451700 |
W C Lumma, R D Hartman, W S Saari, E L Engelhardt, V J Lotti, C A Stone.
Abstract
Regioselective syntheses of substituted 2-chloroquinoxalines and derived 2-(1-piperazinyl)quinoxalines are described. Selectivity in regards to serotonin reuptake blocking and serotoninmimetic activities of the piperazinylquinoxalines is reported. In general, introduction of a 6-substituent into the piperazinylquinoxaline enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted and 3-hydroxypiperazinylquinoxalines had primarily serotoninmimetic activity.Entities:
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Year: 1981 PMID： 6451700 DOI： 10.1021/jm00133a019
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446