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Literature DB >> 6450157

Recurrence risks for Down syndrome.

Abstract

The recurrence risks for Down syndrome due to an inherited translocation are estimated from empirical data in the literature for two maternal age groups: mothers under 30 and mothers 30 and over. These risks were found to be approximately 0.3% and 0.05%, respectively. The probability for two Down syndrome sibs both having an inherited translocation was estimated as about 18.2% for the former age group and 2.7% for the latter. The relative effectiveness in preventing. Down syndrome births by karyotyping affected children is discussed.

Entities: Species

Mesh：

Year: 1980 PMID： 6450157 DOI： 10.1007/bf00291768

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

10 in total

1. A survey of mongoloid births in Victoria, Australia, 1942-1957.

Authors: R D COLLMANN; A STOLLER
Journal: Am J Public Health Nations Health Date: 1962-05

2. A statistical segregation analysis of (21q22q)-translocations.

Authors: J Stene
Journal: Hum Hered Date: 1970 Impact factor: 0.444

Review 3. Down's syndrome. Current stage of cytogenetic research.

Authors: M Mikkelsen
Journal: Humangenetik Date: 1971

4. Genetic counselling in Down's syndrome.

Authors: M Mikkelsen; J Stene
Journal: Hum Hered Date: 1970 Impact factor: 0.444

5. Statistical inference on segregation ratios for D-G-translocations, when the families are ascertained in different ways.

Authors: J Stene
Journal: Ann Hum Genet Date: 1970-07 Impact factor: 1.670

9. Detection of higher recurrence risk for age-dependent chromosome abnormalities with an application to trisomy G1. (Down's syndrome).

Authors: J Stene
Journal: Hum Hered Date: 1970 Impact factor: 0.444

10. [A study of the offspring of t(21q Dq) translocation carriers].

Authors: B Dutrillaux; J Lejeune
Journal: Ann Genet Date: 1969-06

10 in total

3 in total

Recurrence risks for Down syndrome.

1. A survey of mongoloid births in Victoria, Australia, 1942-1957.

2. A statistical segregation analysis of (21q22q)-translocations.

Review 3. Down's syndrome. Current stage of cytogenetic research.

4. Genetic counselling in Down's syndrome.

5. Statistical inference on segregation ratios for D-G-translocations, when the families are ascertained in different ways.

6. 21-22 translocation Down's syndromea family with unusual segregating patterns.

7. Translocation Down's syndrome in Japan: its frequency, mutation rate of translocation and parental age.

8. Consistent and variable chromosome anomalies in parents of children with Down's syndrome.

9. Detection of higher recurrence risk for age-dependent chromosome abnormalities with an application to trisomy G1. (Down's syndrome).

10. [A study of the offspring of t(21q Dq) translocation carriers].

1. [Not Available].

2. Inbreeding and the genetic control of nondisjunction.

3. Genetic epidemiology of Down's syndrome in Shetland.