Literature DB >> 6450052

Nicotinamide administration alters the activities of hepatic microsomal mixed function oxidases.

J K Batra, H G Raj, T A Venkitasubramanian.   

Abstract

Systemic action of nicotinamide significantly alters the activities of hepatic drug metabolizing enzymes. Male rats injected with nicotinamide have reduced levels of cytochrome P450, demethylases and aniline hydroxylase. The changes appear to be sex-dependent since in the case of female rats activities of p-nitroanisole-o-demethylase and aniline hydroxylase are enhanced whereas cytochrome P450 content remains unaltered.

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Year:  1980        PMID： 6450052     DOI： 10.1007/bf01969607

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  10 in total

1.  A reliable, sensitive, and convenient radioactive assay for benzpyrene monooxygenase.

Authors:  J W DePierre; M S Moron; K A Johannesen; L Ernster
Journal:  Anal Biochem       Date:  1975-02       Impact factor: 3.365

2.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

3.  The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.

Authors:  T NASH
Journal:  Biochem J       Date:  1953-10       Impact factor: 3.857

4.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

5.  Inhibition of microsomal drug-metabolizing enzymes from rat liver by various 4-hydroxycoumarin derivatives.

Authors:  F Christensen; F Wissing
Journal:  Biochem Pharmacol       Date:  1972-04-01       Impact factor: 5.858

6.  Ascorbic acid deficiency and induction of hepatic microsomal hydroxylative enzymes by organochlorine pesticides.

Authors:  D J Wagstaff; J C Street
Journal:  Toxicol Appl Pharmacol       Date:  1971-05       Impact factor: 4.219

7.  Hormonal regulation of aminopyrine N-demethylase system in rat liver.

Authors:  S Ichii; N Yago
Journal:  J Biochem       Date:  1969-04       Impact factor: 3.387

8.  Effect of riboflavin deficiency on phenobarbital and 3-methylcholanthrene induction of microsomal drug-metabolizing enzymes of the rat.

Authors:  L Shargel; P Mazel
Journal:  Biochem Pharmacol       Date:  1973-10-01       Impact factor: 5.858

Review 9.  Role of nutrition in the drug-metabolizing enzyme system.

Authors:  T C Campbell; J R Hayes
Journal:  Pharmacol Rev       Date:  1974-09       Impact factor: 25.468

10.  Riboflavin and drug metabolism in adult male and female rats.

Authors:  J M Patel; S S Pawar
Journal:  Biochem Pharmacol       Date:  1974-05-15       Impact factor: 5.858
  10 in total

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