Literature DB >> 6450049

Binding of phencyclidine to rat brain membranes: technical aspect.

J P Vincent, J Vignon, B Kartalovski, M Lazdunski.   

Abstract

[3H]Phencyclidine has a tendency to adsorb to filters used in binding experiments. The spinal binding techniques that should be used to overcome this difficulty are described. The affinity of [3H]phencyclidine for its brain receptor was 4 times higher in a medium containing 5 mM salt than in a medium containing 50 mM salt.

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Year:  1980        PMID: 6450049     DOI: 10.1016/0014-2999(80)90064-3

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN: 0014-2999            Impact factor:   4.432


  3 in total

1.  Phencyclidine (angel dust)/sigma "opiate" receptor: visualization by tritium-sensitive film.

Authors:  R Quirion; R P Hammer; M Herkenham; C B Pert
Journal:  Proc Natl Acad Sci U S A       Date:  1981-09       Impact factor: 11.205

2.  Effects of phencyclidine and its derivatives on enteric neurones.

Authors:  A R Gintzler; R S Zukin; S R Zukin
Journal:  Br J Pharmacol       Date:  1982-02       Impact factor: 8.739

3.  Phencyclidine in nanomolar concentrations binds to synaptosomes and blocks certain potassium channels.

Authors:  M P Blaustein; R K Ickowicz
Journal:  Proc Natl Acad Sci U S A       Date:  1983-06       Impact factor: 11.205

  3 in total

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