Literature DB >> 6449079

Role of ornithine decarboxylase in cardiac growth and hypertrophy.

J Bartolome, J Huguenard, T A Slotkin.   

Abstract

Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.

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Year:  1980        PMID： 6449079     DOI： 10.1126/science.6449079

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  16 in total

1.  Overproduction of cardiac S-adenosylmethionine decarboxylase in transgenic mice.

Authors:  Oleg Nisenberg; Anthony E Pegg; Patricia A Welsh; Kerry Keefer; Lisa M Shantz
Journal:  Biochem J       Date:  2006-01-01       Impact factor: 3.857

2.  Depletion of intracellular polyamines relieves inward rectification of potassium channels.

Authors:  S L Shyng; Q Sha; T Ferrigni; A N Lopatin; C G Nichols
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

3.  Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy.

Authors:  Kale S Bongers; Daniel K Fox; Steven D Kunkel; Larissa V Stebounova; Daryl J Murry; Miles A Pufall; Scott M Ebert; Michael C Dyle; Steven A Bullard; Jason M Dierdorff; Christopher M Adams
Journal:  Am J Physiol Endocrinol Metab       Date:  2014-11-18       Impact factor: 4.310

4.  Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy.

Authors:  C A Mackintosh; D J Feith; L M Shantz; A E Pegg
Journal:  Biochem J       Date:  2000-09-15       Impact factor: 3.857

5.  Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy.

Authors:  L M Shantz; D J Feith; A E Pegg
Journal:  Biochem J       Date:  2001-08-15       Impact factor: 3.857

6.  Norepinephrine-induced enlargement of nucleus in cultured myocardial cells.

Authors:  T Igawa; Y Yamori; L J Lewis; R C Tarazi
Journal:  Heart Vessels       Date:  1988       Impact factor: 2.037

7.  Relationship between the in-situ activity of ornithine decarboxylase and contractile function of the rabbit papillary muscle.

Authors:  R J Boucek; R D Olson; R C Boerth
Journal:  Basic Res Cardiol       Date:  1983 Nov-Dec       Impact factor: 17.165

8.  Catecholamine-induced cardiac hypertrophy in rats is associated with the activation of p70 kinase and c-Jun NH(2)-terminal kinase 2.

Authors:  Monika Leicht; Nora Greipel; Beate Raßler; Heinz-Gerd Zimmer
Journal:  Exp Clin Cardiol       Date:  2002

Review 9.  New paradigms in neuroendocrinology: relationships between obesity, systemic inflammation and the neuroendocrine system.

Authors:  R Toni; A Malaguti; S Castorina; E Roti; R M Lechan
Journal:  J Endocrinol Invest       Date:  2004-02       Impact factor: 4.256

10.  Response of the rat heart to catecholamines and thyroid hormones.

Authors:  H G Zimmer; M Irlbeck; C K Kolbeck-Rühmkorff
Journal:  Mol Cell Biochem       Date:  1995 Jun 7-21       Impact factor: 3.396
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