Literature DB >> 64486

Studies on Brugia pahangi. 13. The anthelmintic effect of compounds F151 (Friedheim), HOE 33258 (Hoechst) and their reaction product.

D A Denham, R R Suswillo, R Rogers, P B McGreevy, B J Andrews.   

Abstract

F151 was a potent filaricide against adult Brugia pahangi in cats and jirds. HOE 33258 did not kill adult worms in cats but had a marginal effect on adult worms in the peritoneal cavity of jirds. It was not immediately microfilaricidal in cats but the microfilarial counts of treated cats fell within a few weeks of treatment. The reaction product, or mixture, of these two compounds (V5851 = E) was strongly macrofilaricidal in cats and jirds.

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Year:  1976        PMID： 64486     DOI： 10.1017/s0022149x00026663

Source DB:  PubMed          Journal:  J Helminthol        ISSN： 0022-149X            Impact factor:   2.170


  3 in total

1.  Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations.

Authors:  C E Bostock-Smith; S A Harris; C A Laughton; M A Searle
Journal:  Nucleic Acids Res       Date:  2001-02-01       Impact factor: 16.971

2.  Sequence-specific interaction of Hoechst 33258 with the minor groove of an adenine-tract DNA duplex studied in solution by 1H NMR spectroscopy.

Authors:  M S Searle; K J Embrey
Journal:  Nucleic Acids Res       Date:  1990-07-11       Impact factor: 16.971

3.  Water at DNA surfaces: ultrafast dynamics in minor groove recognition.

Authors:  Samir Kumar Pal; Liang Zhao; Ahmed H Zewail
Journal:  Proc Natl Acad Sci U S A       Date:  2003-06-18       Impact factor: 11.205
  3 in total

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