| Literature DB >> 6447117 |
M V Lafleur, J Woldhuis, H Loman.
Abstract
The effect of sulphydryl compounds on the induction of alkali-labile sites and on the contribution of such sites to the inactivation of single-stranded phi X174 DNA was studied. Cysteamine is capable of reacting with DNA radicals, thereby modifying the radiation damage in such a way that the induction of immediate and latent breaks is reduced. This depends on the pH of the solution. With cysteine only, a pH dependent protection, against lethal alkali-labile potential breaks could be observed. The damage other than breaks is not influenced by the presence of sulphydryl compounds.Entities:
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Year: 1980 PMID： 6447117 DOI： 10.1080/09553008014550611
Source DB: PubMed Journal: Int J Radiat Biol Relat Stud Phys Chem Med ISSN： 0020-7616