Literature DB >> 6447109

Induction of suppressor T cells in delayed-type hypersensitivity to Mycobacterium bovis BCG in low-responder mice.

R M Nakamura, T Tokunaga.   

Abstract

The induction of delayed-type hypersensitivity to Mycobacterium bovis BCG was specifically inhibited by suppressor T cells in C3H/He, a strain of mice which is a low responder to BCG. The existence of these suppressor cells was confirmed by an adoptive transfer of spleen cells of BCG-injected mice into cyclophosphamide-treated recipients. The suppressor cells appeared in the spleens of the mice 2 to 7 days after intravenous BCG injection. They were sensitive to anti-theta serum and complement and did not adhere to Sephadex G-10. A pretreatment of the mice with cyclophosphamide eliminated the suppression of delayed-type hypersensitivity. These suppressor cells effectively inhibited the induction of delayed-type hypersensitivity to BCG, but showed only weak effect on the expression of it.

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Year:  1980        PMID： 6447109      PMCID： PMC550938          DOI： 10.1128/iai.28.2.331-335.1980

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  18 in total

1.  Studies on the role of suppressor cells in specific unresponsiveness to DNCB.

Authors:  L Polak
Journal:  Immunology       Date:  1976-09       Impact factor: 7.397

2.  Tolerance and contact sensitivity to DNFB in mice. 3. Transfer of tolerance with "suppressor T cells".

Authors:  P Phanupak; J W Moorhead; H N Claman
Journal:  J Immunol       Date:  1974-10       Impact factor: 5.422

3.  Depression of the T cell phenomenon of contact sensitivity by T cells from unresponsive mice.

Authors:  M Zembala; G L Asherson
Journal:  Nature       Date:  1973-07-27       Impact factor: 49.962

4.  Separation of mouse spleen cells by passage through columns of sephadex G-10.

Authors:  I A Ly; R I Mishell
Journal:  J Immunol Methods       Date:  1974-08       Impact factor: 2.303

5.  Role of the thymus in tolerance. X. "Suppressor" activity of antigen-stimulated rat thymocytes transferred to normal recipients.

Authors:  T Y Ha; B H Waksman
Journal:  J Immunol       Date:  1973-05       Impact factor: 5.422

6.  Specific suppression of delayed hypersensitivity skin reactions to collagen in guinea-pigs after immunization with collagen and Freund's incomplete adjuvant.

Authors:  G J Gentner; B C Adelmann
Journal:  Immunology       Date:  1976-07       Impact factor: 7.397

7.  Splenic suppressor macrophages induced in mice by injection of Corynebacterium parvum.

Authors:  H Kirchner; H T Holden
Journal:  J Immunol       Date:  1975-11       Impact factor: 5.422

8.  Immune suppression with supraoptimal doses of antigen in contact sensitivity. I. Demonstration of suppressor cells and their sensitivity to cyclophosphamide.

Authors:  M S Sy; S D Miller; H N Claman
Journal:  J Immunol       Date:  1977-07       Impact factor: 5.422

9.  Potentiation of T-cell-mediated immunity by selective suppression of antibody formation with cyclophosphamide.

Authors:  P H Lagrange; G B Mackaness; T E Miller
Journal:  J Exp Med       Date:  1974-06-01       Impact factor: 14.307

10.  Cyclophosphamide-sensitive T lymphocytes suppress the in vivo generation of antigen-specific cytotoxic T lymphocytes.

Authors:  M Röllinghoff; A Starzinski-Powitz; K Pfizenmaier; H Wagner
Journal:  J Exp Med       Date:  1977-02-01       Impact factor: 14.307
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  20 in total

1.  Killed Listeria-induced suppressor T cells involved in suppression of delayed-type hypersensitivity and protection against Listeria infection.

Authors:  K Yamamoto; K Kato; T Kimura
Journal:  Immunology       Date:  1985-08       Impact factor: 7.397

2.  Scrub typhus vaccine candidate Kp r56 induces humoral and cellular immune responses in cynomolgus monkeys.

Authors:  Suchismita Chattopadhyay; Ju Jiang; Teik-Chye Chan; T Scott Manetz; Chien-Chung Chao; Wei-Mei Ching; Allen L Richards
Journal:  Infect Immun       Date:  2005-08       Impact factor: 3.441

3.  Two types of suppressor T cells that inhibit delayed-type hypersensitivity to Mycobacterium intracellulare in mice.

Authors:  R M Nakamura; Y Goto; K Kitamura; T Tokunaga
Journal:  Infect Immun       Date:  1989-03       Impact factor: 3.441

4.  I-J-positive cloned macrophages as accessory cells for the induction of suppressor T cells in vitro.

Authors:  R M Nakamura; Y Nakamura; A Nagayama; T Tokunaga
Journal:  Immunol Res       Date:  1986       Impact factor: 2.829

5.  Strain difference in delayed-type hypersensitivity to BCG in mice: role of splenic adherent cells in the primary immune response.

Authors:  R M Nakamura; H Tanaka; T Tokunaga
Journal:  Immunology       Date:  1982-12       Impact factor: 7.397

6.  Strain differences in lung granuloma formation in response to a BCG cell-wall vaccine in mice. Failure of antigen presentation by low-responder macrophages.

Authors:  M Kakinuma; K Onoé; R Yasumizu; K Yamamoto
Journal:  Immunology       Date:  1983-11       Impact factor: 7.397

7.  In vivo and in vitro administration of interleukin 2-containing preparation reverses T-cell unresponsiveness in Mycobacterium bovis BCG-infected mice.

Authors:  V Colizzi
Journal:  Infect Immun       Date:  1984-07       Impact factor: 3.441

8.  Cyclophosphamide treatment antagonizes the in vitro development of Mycobacterium lepraemurium-induced suppressor cell precursors.

Authors:  D Gosselin; R Turcotte; S Lemieux
Journal:  Clin Exp Immunol       Date:  1992-08       Impact factor: 4.330

9.  Genetic control of resistance to Mycobacterium intracellulare infection in mice.

Authors:  Y Goto; R M Nakamura; H Takahashi; T Tokunaga
Journal:  Infect Immun       Date:  1984-10       Impact factor: 3.441

10.  Host defenses in experimental scrub typhus: delayed-type hypersensitivity responses of inbred mice.

Authors:  T R Jerrells; J V Osterman
Journal:  Infect Immun       Date:  1982-01       Impact factor: 3.441
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