Literature DB >> 6446408

EGF growth promoting activity is neutralized by phorbol esters.

J F Lechner, M E Kaighn.   

Abstract

The tumor-promoter, TPA, stimulates growth of human epithelial cells but not that of normal fibroblasts. In the presence of either EGF or FGF, TPA antagonizes the growth stimulatory activity of both factors in both cell lines.

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Year:  1980        PMID： 6446408     DOI： 10.1016/0309-1651(80)90005-3

Source DB:  PubMed          Journal:  Cell Biol Int Rep        ISSN： 0309-1651


  5 in total

1.  Inhibition of protein breakdown by epidermal growth factor in IMR90 human fibroblasts and other mammalian cell lines.

Authors:  J M Gunn; J B Bodner; S E Knowles; F J Ballard
Journal:  Biochem J       Date:  1983-01-15       Impact factor: 3.857

2.  Epidermal growth factor is synergistic with phorbol esters and vasopressin in stimulating arachidonate release and prostaglandin production in renal glomerular mesangial cells.

Authors:  B L Margolis; J V Bonventre; S G Kremer; J E Kudlow; K L Skorecki
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

3.  Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts.

Authors:  S J Decker
Journal:  Mol Cell Biol       Date:  1984-09       Impact factor: 4.272

4.  Control of growth and squamous differentiation in normal human bronchial epithelial cells by chemical and biological modifiers and transferred genes.

Authors:  A M Pfeifer; J F Lechner; T Masui; R R Reddel; G E Mark; C C Harris
Journal:  Environ Health Perspect       Date:  1989-03       Impact factor: 9.031

Review 5.  Allosteric regulation of the epidermal growth factor receptor kinase.

Authors:  J Schlessinger
Journal:  J Cell Biol       Date:  1986-12       Impact factor: 10.539
  5 in total

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