| Literature DB >> 6444801 |
A D Callow, C B Ledig, T F O'Donnell, J J Kelly, D Rosenthal, S Korwin, C Hotte, P C Kahn, J J Vecchione, C R Valeri.
Abstract
This paper presents early experience with a primate model for the noninvasive study of the interaction of circulating platelets with healing arterial prostheses. These experiments demonstrate that baboon platelets can be isolated and labeled with 111Indium with high efficiency using a sterile technique. Platelets subjected to this process have a linear life span similar to that of 51Chromium-labeled baboon platelets. The high energy gamma emission of 111Indium oxine allows for external scanning using a standard gamma camera. The small quantity of 111Indium-labeled platelets in the region of the graft can be discriminated from the surrounding blood vessel and quantitated by gamma camera imaging and computer analysis. There was a significant increase in the platelet deposition on prosthetic surfaces observed 5--48 hours after graft implantation and injection of 111Indium-labeled autologous platelets.Entities:
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Year: 1980 PMID： 6444801 PMCID： PMC1344709 DOI： 10.1097/00000658-198003000-00017
Source DB: PubMed Journal: Ann Surg ISSN： 0003-4932 Impact factor: 12.969