Literature DB >> 6444235

Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).

S Broder, D L Mann, T A Waldmann.   

Abstract

We studied the effects of an antiserum to human Ia-like antigens (p23,30) upon the polyclonal activation of normal B cells (cultured with various combination of irradiated and unirradiated T cells) to become immunoglobulin-secreting cells after stimulation with pokeweed mitogen in vitro. We found that the antiserum suppressed immunoglobulin production. The inhibitory effect did not appear to result from a simple interaction at the B-cell/monocyte level alone. Rather, the inhibitory effect required the presence of a radiosensitive subset of autologous suppressor T cells.

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Year:  1980        PMID： 6444235      PMCID： PMC2185755          DOI： 10.1084/jem.151.1.257

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  24 in total

1.  Inhibition of proliferative and plaque-forming cell responses by human bone-marrow-derived lymphocytes from peripheral blood by antisera to the p23, 30 antigen.

Authors:  S M Friedman; J M Breard; R E Humphreys; J L Strominger; S F Schlossman; L Chess
Journal:  Proc Natl Acad Sci U S A       Date:  1977-02       Impact factor: 11.205

2.  Immunoglobulin E in immunologic deficiency diseases. II. Serum IgE concentration of patients with acquired hypogammaglobulinemia, thymoma and hypogammaglobulinemia, myotonic dystrophy, intestinal lymphangiectasia and Wiskott-Aldrich syndrome.

Authors:  T A Waldmann; S H Polmar; S T Balestra; M C Jost; R M Bruce; W D Terry
Journal:  J Immunol       Date:  1972-08       Impact factor: 5.422

3.  Serological identification of five HLA-D associated (Ia-like) determinants.

Authors:  D Albrechtsen; B G Solheim; E Thorsby
Journal:  Tissue Antigens       Date:  1977-03

Review 4.  The Ia antigens.

Authors:  D H Sachs
Journal:  Contemp Top Mol Immunol       Date:  1976

5.  The H-2 major histocompatibility complex and the I immune response region: genetic variation, function, and organization.

Authors:  D C Shreffler; C S David
Journal:  Adv Immunol       Date:  1975       Impact factor: 3.543

Review 6.  Genetic and functional analysis of the Ia antigens: their possible role in regulating the immune response.

Authors:  H O McDevitt; T L Delovitch; J L Press; D B Murphy
Journal:  Transplant Rev       Date:  1976

Review 7.  B-cell antibodies, Ia-like determinants, and their relation to MLC determinants in man.

Authors:  J J van Rood; A van Leeuwen; A Termijtelen; J J Keuning
Journal:  Transplant Rev       Date:  1976

8.  The Sézary syndrome: a malignant proliferation of helper T cells.

Authors:  S Broder; R L Edelson; M A Lutzner; D L Nelson; R P MacDermott; M E Durm; C K Goldman; B D Meade; T A Waldmann
Journal:  J Clin Invest       Date:  1976-12       Impact factor: 14.808

9.  Recognition by pregnancy serums of non-HL-A alloantigens selectively expressed on B lymphocytes.

Authors:  R J Winchester; P Wernet; H G Kunkel; B Dupont; C Jersild; S M Fu
Journal:  J Exp Med       Date:  1975-04-01       Impact factor: 14.307

10.  Alloantiserum-mediated suppression of histocompatibility-linked Ir-gene-controlled immune responses. Suppressive effects of IgG fragments derived from alloantisera.

Authors:  H G Bluestein
Journal:  J Exp Med       Date:  1974-08-01       Impact factor: 14.307
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  9 in total

1.  Mechanism of regulation of immune responses by in vivo administration of monoclonal anti-I-A antibodies.

Authors:  M I Greene; L Perry; A Carroll; A Lowy
Journal:  Surv Immunol Res       Date:  1985

2.  Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

Authors:  C Boitard; A Bendelac; M F Richard; C Carnaud; J F Bach
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.

Authors:  D A Shackelford; D L Mann; J J van Rood; G B Ferrara; J L Strominger
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

4.  Dysfunctions of pokeweed mitogen-stimulated T and B lymphocyte responses induced by gammaglobulin therapy.

Authors:  A Durandy; A Fischer; C Griscelli
Journal:  J Clin Invest       Date:  1981-03       Impact factor: 14.808

5.  In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.

Authors:  J T Rosenbaum; N E Adelman; H O McDevitt
Journal:  J Exp Med       Date:  1981-11-01       Impact factor: 14.307

6.  Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.

Authors:  N E Adelman; D L Watling; H O McDevitt
Journal:  J Exp Med       Date:  1983-10-01       Impact factor: 14.307

7.  Serologic identification of the human secondary B cell antigens. Correlations between function, genetics, and structure.

Authors:  S Shaw; R DeMars; S F Schlossman; P L Smith; L A Lampson; L M Nadler
Journal:  J Exp Med       Date:  1982-09-01       Impact factor: 14.307

8.  Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies.

Authors:  L L Perry; M I Greene
Journal:  J Exp Med       Date:  1982-08-01       Impact factor: 14.307

9.  Antigen-specific T cell clones restricted to unique F1 major histocompatibility complex determinants. Inhibition of proliferation with monoclonal anti-Ia antibody.

Authors:  B Sredni; L A Matis; E A Lerner; W E Paul; R H Schwartz
Journal:  J Exp Med       Date:  1981-03-01       Impact factor: 14.307
  9 in total

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