Enhancement by intracerebroventricular thyrotropin-releasing hormone of indomethacin-induced gastric lesions in the rat.

Effects of the intracerebroventricular thyrotropin-releasing hormone (TRH) on gastric mucosa were studied in rats. TRH (3 and 10 micrograms rat-1 i.c.v.) produced slight gastric lesions and also aggravated indomethacin-, aspirin- or 5-hydroxytryptamine (5-HT)-induced gastric lesions, while restraint and cold stress-induced lesions were not influenced by TRH. Bethanechol used at a dose sufficient to produce acid secretion did not influence the gastric mucosa in intact or indomethacin-treated rats. Enhancement of indomethacin-induced gastric lesions by TRH was not inhibited to any significant degree by atropine 0.1 mg kg-1 s.c., which prevented TRH-induced gastric acid secretion, but tended to be inhibited by phentolamine, 2.5 mg kg-1 i.p. It is concluded that the enhancement by TRH of indomethacin-induced gastric lesions is due to a combination of the central and peripheral actions of the ulcerogenic agents.