Temocillin: in vitro activity against 734 selected clinical isolates, including beta-lactamase-producing strains.

The in vitro activity of temocillin against 734 clinical isolates was tested by broth microdilution. Good activity was demonstrated against Enterobacteriaceae and both beta-lactamase-positive and -negative strains of Haemophilus influenzae and Neisseria gonorrhoeae. There was little to no activity against gram-positive cocci and nonfermenting gram-negative bacilli. Bactericidal activity and effect of inoculum size on temocillin activity were comparable to that of ticarcillin. Temocillin was stable to commonly encountered beta-lactamases and significantly inhibited Richmond-Sykes type 1 enzymes of Enterobacter cloacae.