Literature DB >> 644310

Norepinephrine in chronic paranoid schizophrenia: above-normal levels in limbic forebrain.

I J Farley, K S Price, E McCullough, J H Deck, W Hordynski, O Hornykiewicz.   

Abstract

In postmortem examination of brains of four patients with chronic paranoid schizophrenia, above-normal norepinephrine levels were measured in the ventral septum, the bed nucleus of the stria terminalis, the nucleus accumbens, and the mammillary bodies. No changes were detected in other limbic forebrain regions, including the hypothalamus and the medial olfactory (preoptic) area. The results point to the possibility of a malfunction of limbic noradrenergic mechanisms in schizophrenia, especially the paranoid variety.

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Year:  1978        PMID： 644310     DOI： 10.1126/science.644310

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  22 in total

1.  Neonatal quinpirole treatment enhances locomotor activation and dopamine release in the nucleus accumbens core in response to amphetamine treatment in adulthood.

Authors:  Zackary A Cope; Kimberly N Huggins; A Brianna Sheppard; Daniel M Noel; David S Roane; Russell W Brown
Journal:  Synapse       Date:  2010-04       Impact factor: 2.562

2.  Noradrenergic β-Adrenoceptor-Mediated Intracellular Molecular Mechanism of Na-K ATPase Subunit Expression in C6 Cells.

Authors:  Megha Amar; Abhishek Singh; Birendra Nath Mallick
Journal:  Cell Mol Neurobiol       Date:  2017-03-28       Impact factor: 5.046

3.  Relationship between plasma concentration and arousal in normal subjects after single oral and parenteral doses of melperone, a butyrophenone neuroleptic.

Authors:  L Molander; L Borgström
Journal:  Psychopharmacology (Berl)       Date:  1983       Impact factor: 4.530

4.  Long-term neuroleptic treatment of chronic schizophrenic patients: clinical and biochemical effects of withdrawal.

Authors:  K J Zander; B Fischer; R Zimmer; M Ackenheil
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

5.  Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing.

Authors:  Kathleen Askland; Cynthia Read; Chloe O'Connell; Jason H Moore
Journal:  Hum Genet       Date:  2011-08-25       Impact factor: 4.132

6.  The relative role of dopamine and norepinephrine receptor blockade in the action of antipsychotic drugs: metoclopramide, thiethylperazine, and molindone as pharmacological tools.

Authors:  S E Robinson; S Berney; R Mishra; F Sulser
Journal:  Psychopharmacology (Berl)       Date:  1979-08-08       Impact factor: 4.530

7.  Hypersensitivity to d-amphetamine several years after early social deprivation in rhesus monkeys.

Authors:  G W Kraemer; M H Ebert; C R Lake; W T McKinney
Journal:  Psychopharmacology (Berl)       Date:  1984       Impact factor: 4.530

8.  Electrophysiologic interactions of antipsychotic drugs with central noradrenergic pathways.

Authors:  J Marwaha; B J Hoffer; H M Geller; R Freedman
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

9.  Cloning, expression, and functional analysis of rhesus monkey trace amine-associated receptor 6: evidence for lack of monoaminergic association.

Authors:  Zhihua Xie; Eric J Vallender; Naichen Yu; Shelli L Kirstein; Hong Yang; Mary E Bahn; Susan V Westmoreland; Gregory M Miller
Journal:  J Neurosci Res       Date:  2008-11-15       Impact factor: 4.164

10.  Effects of pharmacological doses of 2-deoxyglucose on plasma catecholamines and glucose levels in patients with schizophrenia.

Authors:  Igor Elman; David Rott; Alan I Green; Daniel D Langleben; Scott E Lukas; David S Goldstein; Alan Breier
Journal:  Psychopharmacology (Berl)       Date:  2004-06-04       Impact factor: 4.530
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