Literature DB >> 6442200

Cultured human monocytes and fibroblasts solubilize calcium phosphate crystals.

R W Evans, H S Cheung, D J McCarty.   

Abstract

Two rheumatic syndromes associated with deposition of calcium phosphate crystals in soft tissues of the shoulder have prompted us to study the cellular mechanisms of calcium phosphate crystal solubilization. Synthetic 45Ca labeled calcium phosphate crystal aggregates were solubilized by cultured human fibroblasts or monocytes. Such solubilization required crystal cell contact and was inhibited by chloroquine and ammonium. We hypothesize that the mechanism of crystal solubilization involves phagocytosis followed by dissolution in the acidic environment of secondary lysosomes. Study of the mechanism of calcium phosphate solubilization may be important in understanding resorption of extra-osseus as well as osseus calcification. Intracellular release of calcium from calcium phosphate crystals may also explain our previous observation that hydroxyapatite and other calcium-containing crystals are mitogenic stimuli for fibroblasts and synovial cells.

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Year:  1984        PMID： 6442200     DOI： 10.1007/bf02405384

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  19 in total

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Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

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Journal:  Arthritis Rheum       Date:  1981-03

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Authors:  H K Uhthoff; K Sarkar; J A Maynard
Journal:  Clin Orthop Relat Res       Date:  1976 Jul-Aug       Impact factor: 4.176

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Journal:  Lab Invest       Date:  1980-04       Impact factor: 5.662

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Authors:  A J Kahn; C C Stewart; S L Teitelbaum
Journal:  Science       Date:  1978-03-03       Impact factor: 47.728

8.  Crystal populations in human synovial fluid. Identification of apatite, octacalcium phosphate, and tricalcium phosphate.

Authors:  D J McCarty; J R Lehr; P B Halverson
Journal:  Arthritis Rheum       Date:  1983-10

9.  Chloroquine, hydroxystilbamidine, and dapsone inhibit resorption of fetal rat bone in organ culture.

Authors:  G Eilon; L G Raisz
Journal:  Calcif Tissue Int       Date:  1982-09       Impact factor: 4.333

10.  Accumulation of weak bases in relation to intralysosomal pH in cultured human skin fibroblasts.

Authors:  M Hollemans; R O Elferink; P G De Groot; A Strijland; J M Tager
Journal:  Biochim Biophys Acta       Date:  1981-04-22
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  10 in total

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Authors:  D J McCarty
Journal:  Trans Am Clin Climatol Assoc       Date:  1991

2.  Basic calcium phosphate crystals activate human osteoarthritic synovial fibroblasts and induce matrix metalloproteinase-13 (collagenase-3) in adult porcine articular chondrocytes.

Authors:  G M McCarthy; P R Westfall; I Masuda; P A Christopherson; H S Cheung; P G Mitchell
Journal:  Ann Rheum Dis       Date:  2001-04       Impact factor: 19.103

3.  Chemical changes in hydroxyapatite biomaterial under in vivo and in vitro biological conditions.

Authors:  I Orly; M Gregoire; J Menanteau; M Heughebaert; B Kerebel
Journal:  Calcif Tissue Int       Date:  1989-07       Impact factor: 4.333

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Authors:  J L Owens; H S Cheung; D J McCarty
Journal:  Calcif Tissue Int       Date:  1986-03       Impact factor: 4.333

5.  Microliths in normal salivary glands of cat investigated by light and electron microscopy.

Authors:  A Triantafyllou; J D Harrison; J R Garrett
Journal:  Cell Tissue Res       Date:  1993-05       Impact factor: 5.249

6.  Endocytosis is required for the mitogenic effect of basic calcium phosphate crystals in fibroblasts.

Authors:  A Borkowf; H S Cheung; D J McCarty
Journal:  Calcif Tissue Int       Date:  1987-03       Impact factor: 4.333

7.  Ultrastructural study of the long-term development of two experimental cutaneous calcinoses (topical calciphylaxis and topical calcergy) in the rat.

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Journal:  Cell Tissue Res       Date:  1987-03       Impact factor: 5.249

8.  Pyrophosphate Stimulates Differentiation, Matrix Gene Expression and Alkaline Phosphatase Activity in Osteoblasts.

Authors:  Michael Pujari-Palmer; Shiuli Pujari-Palmer; Xi Lu; Thomas Lind; Håkan Melhus; Thomas Engstrand; Marjam Karlsson-Ott; Hakan Engqvist
Journal:  PLoS One       Date:  2016-10-04       Impact factor: 3.240

9.  Osteoarthritis-associated basic calcium phosphate crystals activate membrane proximal kinases in human innate immune cells.

Authors:  Emma M Corr; Clare C Cunningham; Laura Helbert; Geraldine M McCarthy; Aisling Dunne
Journal:  Arthritis Res Ther       Date:  2017-02-07       Impact factor: 5.156

10.  Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state.

Authors:  Ashika Chhana; Bregina Pool; Karen E Callon; Mei Lin Tay; David Musson; Dorit Naot; Geraldine McCarthy; Susan McGlashan; Jillian Cornish; Nicola Dalbeth
Journal:  Arthritis Res Ther       Date:  2018-09-10       Impact factor: 5.156
  10 in total

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