Literature DB >> 6441803

Different tissue distributions of two types of thiol proteinase inhibitors from rat liver and epidermis.

E Kominami, Y Bando, N Wakamatsu, N Katunuma.   

Abstract

The concentrations of two types of endogenous inhibitors of thiol proteinases were determined in soluble extracts of various rat tissues by means of a sensitive enzyme immunoassay method, which consisted of solid-phase immobilized anti-rat liver inhibitor or anti-rat epidermal inhibitor and antibodies labeled with horseradish peroxidase. The minimum detectable amounts of inhibitors from liver and epidermis were 30 pg and 3 pg/assay, respectively. The tissue distributions of the epidermal and liver-type inhibitors were found to differ. The liver-type inhibitor was found to be widely distributed in various tissues at levels of 76-420 ng/mg protein, whereas the epidermal-type inhibitor was found at high levels in the skin, tongue, esophagus, stomach, intestine, and vagina, but at quite low levels in other tissues tested.

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Year:  1984        PMID： 6441803     DOI： 10.1093/oxfordjournals.jbchem.a134972

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  11 in total

1.  Biological and prognostic role of acid cysteine proteinase inhibitor (ACPI, cystatin A) in non-small-cell lung cancer.

Authors:  T Leinonen; R Pirinen; J Böhm; R Johansson; A Rinne; E Weber; V-M Kosma
Journal:  J Clin Pathol       Date:  2006-06-21       Impact factor: 3.411

2.  Immunocytochemical localization of cathepsins B, H, and L in the rat gastro-duodenal mucosa.

Authors:  M Furuhashi; A Nakahara; H Fukutomi; E Kominami; D Grube; Y Uchiyama
Journal:  Histochemistry       Date:  1991

3.  Abnormal distribution of cathepsin proteinases and endogenous inhibitors (cystatins) in the hippocampus of patients with Alzheimer's disease, parkinsonism-dementia complex on Guam, and senile dementia and in the aged.

Authors:  K Ii; H Ito; E Kominami; A Hirano
Journal:  Virchows Arch A Pathol Anat Histopathol       Date:  1993

4.  Variations in immunocytochemical localization of cathepsin B and thyroxine in follicular cells of the rat thyroid gland and plasma TSH concentrations over 24 hours.

Authors:  Y Uchiyama; M Watanabe; T Watanabe; Y Ishii; H Matsuba; S Waguri; E Kominami
Journal:  Cell Tissue Res       Date:  1989       Impact factor: 5.249

5.  Immunocytochemical localization of cathepsins B and H in human pancreatic endocrine cells and insulinoma cells.

Authors:  B Im; E Kominami; D Grube; Y Uchiyama
Journal:  Histochemistry       Date:  1989

6.  Abnormal increases of lysosomal cysteinine proteinases in rimmed vacuoles in the skeletal muscle.

Authors:  K Ii; K Hizawa; I Nonaka; H Sugita; E Kominami; N Katunuma
Journal:  Am J Pathol       Date:  1986-02       Impact factor: 4.307

7.  Aggregation of macrophages in the tips of intestinal villi in guinea pigs: their possible role in the phagocytosis of effete epithelial cells.

Authors:  H Han; T Iwanaga; Y Uchiyama; T Fujita
Journal:  Cell Tissue Res       Date:  1993-03       Impact factor: 5.249

8.  Increased expression of the stefin A cysteine proteinase inhibitor occurs in the myelomonocytic cell-infiltrated tissues of autoimmune motheaten mice.

Authors:  I Mlinaric-Rascan; S L Asa; K A Siminovitch
Journal:  Am J Pathol       Date:  1994-10       Impact factor: 4.307

9.  Demonstration of cathepsins B, H and L in xenografts of normal and Duchenne-muscular-dystrophy muscles transplanted into nude mice.

Authors:  A Takeda; T Jimi; Y Wakayama; N Misugi; S Miyake; T Kumagai
Journal:  Biochem J       Date:  1992-12-01       Impact factor: 3.857

10.  Posttranslational processing and modification of cathepsins and cystatins.

Authors:  Nobuhiko Katunuma
Journal:  J Signal Transduct       Date:  2010-12-16
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