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Literature DB >> 6441736

Tyrosinase-like activity in normal human substantia nigra.

M Miranda, D Botti, A Bonfigli, T Ventura, A Arcadi.

Abstract

A tyrosinase-like activity was found in human substantia nigra by polyacrylamide gel electrophoresis of fractions prepared from homogenates of the substantia nigra. The enzyme activity was detected by staining the gels with L-3,4-dihydroxyphenylalanine, dopamine and 5,6-dihydroxyindole as substrates for tyrosinase (EC 1.14.18.1). A case of parkinsonism does not show the L-3,4-dihydroxyphenylalanine and dopamine oxidase activities.

Entities: Chemical Disease Gene Species

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Year: 1984 PMID： 6441736 DOI： 10.1016/0306-3623(84)90212-x

Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623

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Cited

18 in total

1. Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase.

Authors: M Rios; B Habecker; T Sasaoka; G Eisenhofer; H Tian; S Landis; D Chikaraishi; S Roffler-Tarlov
Journal: J Neurosci Date: 1999-05-01 Impact factor: 6.167

Review 2. Neuromelanin in Parkinson's Disease: from Fenton Reaction to Calcium Signaling.

Authors: Rainer Knörle
Journal: Neurotox Res Date: 2017-09-06 Impact factor: 3.911

3. 2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin.

Authors: P A Rosenberg; R Loring; Y Xie; V Zaleskas; E Aizenman
Journal: Proc Natl Acad Sci U S A Date: 1991-06-01 Impact factor: 11.205

4. Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification.

Authors: F Solano; V J Hearing; J C García-Borrón
Journal: Neurotox Res Date: 2000-02 Impact factor: 3.911

Review 5. Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.

Authors: Masato Asanuma; Ikuko Miyazaki; Norio Ogawa
Journal: Neurotox Res Date: 2003 Impact factor: 3.911

10. Heritable differences in the dopaminergic regulation of sensorimotor gating. I. Apomorphine effects on startle gating in albino and hooded outbred rat strains and their F1 and N2 progeny.

Authors: Neal R Swerdlow; Jody M Shoemaker; Amanda Platten; Leia Pitcher; Jana Goins; Pamela P Auerbach
Journal: Psychopharmacology (Berl) Date: 2003-05-21 Impact factor: 4.530

Tyrosinase-like activity in normal human substantia nigra.

1. Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase.

Review 2. Neuromelanin in Parkinson's Disease: from Fenton Reaction to Calcium Signaling.

3. 2,4,5-trihydroxyphenylalanine in solution forms a non-N-methyl-D-aspartate glutamatergic agonist and neurotoxin.

4. Neurotoxicity due to o-quinones: neuromelanin formation and possible mechanisms for o-quinone detoxification.

Review 5. Dopamine- or L-DOPA-induced neurotoxicity: the role of dopamine quinone formation and tyrosinase in a model of Parkinson's disease.

Review 6. Olive Oil Polyphenols in Neurodegenerative Pathologies.

Review 7. Tyrosinase-expressing neuronal cell line as in vitro model of Parkinson's disease.

8. Neuromelanin Modulates Heterocyclic Aromatic Amine-Induced Dopaminergic Neurotoxicity.

9. Neuromelanin formation exacerbates HAA-induced mitochondrial toxicity and mitophagy impairments.

10. Heritable differences in the dopaminergic regulation of sensorimotor gating. I. Apomorphine effects on startle gating in albino and hooded outbred rat strains and their F1 and N2 progeny.