Influence of prostaglandin synthetase inhibitors on the renal effects of histamine.

The increase in renal blood flow and accompanying increase in excretion of electrolytes (e.g., Na+, Ca2+, and other osmolar constituents) produced by intra-renal arterial infusion of histamine in dogs are reduced by the inhibitors of cyclooxygenase activity, indomethacin and RO 20-5720, given intravenously. This suggests the possibility that histamine might be acting in conjunction with the renal prostanoids, either by stimulating their release by activating prostaglandin synthesis, or by acting at the PG receptor sites in a similar manner.