Literature DB >> 6440665

[Regional distribution of enkephalinase in the rat brain by autoradiography].

G Waksman, E Hamel, R Bouboutou, R Besselièvre, M C Fournié-Zaluski, B P Roques.   

Abstract

The first visualization of enkephalinase (neutral metalloendopeptidase, E.C.3.4.24.11) in rat brain was obtained by autoradiography, using a new tritiated inhibitor: [3H]N-[( R,S )3-(N-hydroxy) carboxamido-2-benzyl propanoyl]glycine (3H-HCBP-Gly). The preliminary analysis of sections clearly showed a discrete localization of enkephalinase in enkephalin enriched regions, such as caudate nucleus, putamen, globus pallidus, and substantia nigra. Moreover 3H-HCBP-Gly binding also occurred in choroid plexus and spinal cord.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6440665

Source DB:  PubMed          Journal:  C R Acad Sci III        ISSN： 0764-4469


  3 in total

1.  Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain.

Authors:  G Waksman; E Hamel; M C Fournié-Zaluski; B P Roques
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

2.  Development of [125I]RB104, a potent inhibitor of neutral endopeptidase 24.11, and its use in detecting nanogram quantities of the enzyme by "inhibitor gel electrophoresis".

Authors:  M C Fournié-Zaluski; J M Soleilhac; S Turcaud; R Laï-Kuen; P Crine; A Beaumont; B P Roques
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

Review 3.  Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Authors:  Brigitte Bauvois; Daniel Dauzonne
Journal:  Med Res Rev       Date:  2006-01       Impact factor: 12.944
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.