Literature DB >> 6439475

Composition of phospholipids and free fatty acids and incorporation of labeled arachidonic acid in rabbit cornea. Comparison of epithelium, stroma and endothelium.

H E Bazan, N G Bazan.   

Abstract

Fatty acid composition of phospholipids and free fatty acids were analyzed in the epithelium, stroma and endothelium of rabbit corneas. Phospholipids from endothelium had the highest proportion of arachidonate and epithelium had the lowest degree of unsaturation. Epithelium had the highest levels of free arachidonic acid. Labeled arachidonic acid was incorporated into membrane lipids of the three layers, primarily in phosphatidylcholine, phosphatidylinositol and triacylglycerols. In conclusion, the three layers of the cornea differ in the fatty acid composition of membrane lipids, particularly with regard to the polyunsaturated chains, and in the metabolism of the arachidonate chain.

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Year:  1984        PMID： 6439475     DOI： 10.3109/02713688409007418

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  10 in total

1.  Phospholipidomic Studies in Human Cornea From Climatic Droplet Keratopathy.

Authors:  Maria Fernanda Suarez; Maria Carmen Piqueras; Leandro Correa; Evangelina Esposito; Maria Fernanda Barros; Sanjoy K Bhattacharya; Julio A Urrets-Zavalia; Horacio M Serra
Journal:  J Cell Biochem       Date:  2017-05-23       Impact factor: 4.429

Review 2.  Omega-3 fatty acids in dry eye and corneal nerve regeneration after refractive surgery.

Authors:  Jiucheng He; Haydee E P Bazan
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2010-03-03       Impact factor: 4.006

3.  The PEDF Neuroprotective Domain Plus DHA Induces Corneal Nerve Regeneration After Experimental Surgery.

Authors:  Jiucheng He; M Soledad Cortina; Azucena Kakazu; Haydee E P Bazan
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-06       Impact factor: 4.799

4.  Oxygen free radical damage in the cornea after excimer laser therapy.

Authors:  S Hayashi; S Ishimoto; G S Wu; W R Wee; N A Rao; P J McDonnell
Journal:  Br J Ophthalmol       Date:  1997-02       Impact factor: 4.638

Review 5.  Significance of lipid mediators in corneal injury and repair.

Authors:  Sachidananda Kenchegowda; Haydee E P Bazan
Journal:  J Lipid Res       Date:  2009-11-03       Impact factor: 5.922

6.  Neuroprotectin D1 synthesis and corneal nerve regeneration after experimental surgery and treatment with PEDF plus DHA.

Authors:  M Soledad Cortina; Jiucheng He; Na Li; Nicolas G Bazan; Haydee E P Bazan
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-09-24       Impact factor: 4.799

7.  Involvement of pigment epithelium-derived factor, docosahexaenoic acid and neuroprotectin D1 in corneal inflammation and nerve integrity after refractive surgery.

Authors:  S Kenchegowda; J He; H E P Bazan
Journal:  Prostaglandins Leukot Essent Fatty Acids       Date:  2012-05-10       Impact factor: 4.006

8.  Omega-3 essential fatty acids therapy for dry eye syndrome: a meta-analysis of randomized controlled studies.

Authors:  Aihua Liu; Jian Ji
Journal:  Med Sci Monit       Date:  2014-09-06

9.  Novel RvD6 stereoisomer induces corneal nerve regeneration and wound healing post-injury by modulating trigeminal transcriptomic signature.

Authors:  Thang L Pham; Azucena H Kakazu; Jiucheng He; Bokkyoo Jun; Nicolas G Bazan; Haydee E P Bazan
Journal:  Sci Rep       Date:  2020-03-12       Impact factor: 4.379

10.  Defining a mechanistic link between pigment epithelium-derived factor, docosahexaenoic acid, and corneal nerve regeneration.

Authors:  Thang Luong Pham; Jiucheng He; Azucena H Kakazu; Bokkyoo Jun; Nicolas G Bazan; Haydee E P Bazan
Journal:  J Biol Chem       Date:  2017-09-26       Impact factor: 5.157
  10 in total

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